The increase in tumor oxygenation under carbogen breathing induces a decrease in the uptake of [18F]-fluoro-deoxy-glucose

We investigated the impact of oxygenation status (measured by EPR oximetry) on the uptake of 18F-FDG (measured by PET) in two different tumor models during a carbogen breathing challenge. We observed a significant drop in 18F-FDG uptake under carbogen breathing that suggests a rapid metabolic adaptation to the oxygen environment.