Dose-effect relation in stereotactic radiotherapy for brain metastases. A systematic review

Local control after single fraction SRT is highly dependent upon dose and is high (>80%) after 21 Gy or more, but low (<50%) after 15 Gy or less. We conclude that SRT for brain metastases should preferably be applied with a BED12 of at least 40 Gy corresponding with a single fraction of 20 Gy, two fractions of 11.6 Gy or three fractions of 8.5 Gy.