Molecular determinants of TRPC1 regulation within ER-PM junctions

- Assembly of STIM1 with Orai1 and TRPC within the ER-PM junctions lead to the gating and regulation of the channels.
- STIM2 and STIM1 tune channel activity to varying degrees of ER-Ca2+ store depletion.
- Integrity of ER-PM junctions are dependent on lipid as well as protein components.
- Dynamic remodeling of ER-PM junctions is critical for regulation of SOCE and Ca2+-dependent cell function.