Keywords: HHC; Human Hepatocellular Carcinoma; LCSLC; sliver cancer stem-like cells; TRPV2; Transient Receptor Potential Vanilloid-type 2 channel; TRP; Transient Receptor Potential; SCID; severe combined immunodeficiency; ALDH1; aldehyde dehydrogenase 1; GFP; green
مقالات ISI (ترجمه نشده)
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Keywords: cAMP; cyclic adenosine monophosphate; GPCRs; G protein-coupled receptors; GLP-1; glucagon-like peptide 1; ATP; adenosine triphosphate; cGMP; cyclic guanosine monophosphate; Na+/K+/ATPase; sodium-potassium adenosine triphosphatase; TRPC; transient recept
Keywords: 3-MP; 3-mercaptopyruvate; 3-MST; 3-mercaptopyruvate sulfurtransferase; AAT; aspartate amino transferase; AE1; anion exchanger-1; AGEs; advanced glycation end products; AKI; acute kidney injury; AMPK; AMP-activated protein kinase; AT1; angiotensin receptor
Keywords: AC; adenylate cyclase; Actn4; α-Actinin-4; ARF6; ADP-ribosylation factor 6; ATD; amino terminal domain; CAIN; calcineurin inhibitor protein; CaM; calmodulin; CaMKII; Ca2+/calmodulin-dependent protein kinase II; Cbln1; cerebellin 1 precursor; CC; coiled-c
Keywords: Systemic lupus erythematosus; Lupus nephritis; Podocytes; Lupus mice model; Immunosuppressive drugs; CD2AP; CD2-associated protein; TRPC; transient receptor potential canonical; IL; interleukin; TNFα; tumoral necrosis factor-alpha; IFNγ; interferon-gamm
Keywords: Prostate cancer; Calcium channels; STIM1; Orai1; TRPC
Keywords: Ca2+ channel; K+ channel; Ca2+-activated Clâ channel; Transcription; Pre-mRNA splicing; Protein degradation; AD; Alzheimer's disease; ADPR; ADP ribose; AITC; allyl isothiocyanate; AKAP; A-kinase anchoring protein; AMPK; 5â² AMP-activated protein kinase
Keywords: Copper; Cardiac hypertrophy; CCO; Angiogenesis; VEGFRs; HIF-1; ANG-1; angiopoietin-1; ANG-2; angiopoietin-2; ANP; atrial natriuretic peptide; ATOX1; antioxidant 1; ATP; adenosine triphosphate; BNP; B-type natriuretic peptide; BNIP3; BCL2/adenovirus E1B 19
Keywords: Mechano-electric feedback; Electrophysiology; Stretch-activated ion channels; Calcium handling; Technology; AP; action potential; Ca2+; calcium; GsMTx-4; Grammostola spatulata mechanotoxin-4; MEC; mechano-electric coupling; TRPC; transient receptor potent
Keywords: ACE; Angiotensin converting enzyme; CaMKII; Ca2Â +/calmodulin-dependent protein kinase II; CaV3; Caveolin 3; CICR; Ca2Â +-induced Ca2Â + release; DMD; Duchenne muscular dystrophy; ECC; Excitation-Contraction Coupling; ISO; Isoproterenol; NCX; Na+-Ca2Â
Keratinocytes negatively regulate the N-cadherin levels of melanoma cells via contact-mediated calcium regulation
Keywords: Melanoma; Melanocyte; Keratinocyte; N-cadherin; Cell-cell interaction; TRPC; transient receptor potential cation channel; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; ECM; extracellular matrix;
The role of TRPV4 in fibrosis
Keywords: α-SMA; α-smooth muscle actin; aa; amino acids; AHF; alcohol/high fat diet; AIP4; atrophin-interacting protein 4; ANK; ankyrin; ARS-L; arachidonate-like recognition sequence; ASL; airway surface liquid; BKCa; Ca2 +-dependent K+; [Ca2 +]i; intracellular
TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation
Keywords: Diabetic retinopathy; Reactive metabolites; TRPC cation channels; MethylGlyoxal; Vasoregression; Glyoxalase1; DR; Diabetic Retinopathy; GLO1; Glyoxalase 1; GSH; Glutathione; GSSG; Glutathione disulfide; HTA; Hemithioacetal; MEF; Mouse Embryonic Fibroblast
An automated epifluorescence microscopy imaging assay for the identification of phospho-AKT level modulators in breast cancer cells
Keywords: Assay development; Automated microscopy; Breast cancer; Calcium channels; Gene silencing; High content analysis; EGF; Epidermal growth factor; EGFR; Epidermal growth factor receptor; EMT; Epithelial mesenchymal transition; HER2; Human epidermal growth fac
Topotecan prevents hypoxia-induced pulmonary arterial hypertension and inhibits hypoxia-inducible factor-1α and TRPC channels
Keywords: PAH; TRPC; TPT; Hypoxia; HIF-1α;
Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer
Keywords: Nonselective cation channels; TRPC channels; Ca2+ signaling; Anticancer; Drug discovery; [Ca2+]i; Intracellular Ca2+ concentration; CCh; Carbachol; EC50; Half maximal stimulation; FMP; FLIPR membrane potential; PLC; phospholipase C; SAR; Structure-activit
Efferocytosis in atherosclerotic lesions: Malfunctioning regulatory pathways and control mechanisms
Keywords: ABC; ATP-binding cassette; ABCA1; ATP-binding membrane cassette transporter A1; ABCG1; ATP binding cassette transporter G1; ABCA7; ATP-binding cassette transporters A7; Abs; Antibodies; ACs; Apoptotic cells; AICAR; 5-aminoimidazole-4-carboxamide-1-β-d-ri
TRPC1, Orai1, and STIM1 in SOCE: Friends in tight spaces
Keywords: TRPC; STIM1; Orai1; SOCE; ER-PM junctions; Lipid rafts; Caveolin;
HIV Tat excites D1 receptor-like expressing neurons from rat nucleus accumbens
Keywords: Calcium imaging; Intracellular calcium mobilization; Calcium influx; Depolarization; TRPC; Medium spiny neurons;
Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells
Keywords: CBS; cystathionine β-synthase; CSE; cystathionine γ-lyase; Drp1; dynamin-related protein 1; 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; ERK; extracellular signal-regulated kinase; G protein; GTP-binding protein; GC; guanylate cyclase; GDP; guanosine 5'
Salvianolic acid B attenuates doxorubicin-induced ER stress by inhibiting TRPC3 and TRPC6 mediated Ca2+ overload in rat cardiomyocytes
Keywords: Doxorubicin; Salvianolic acid B; Cardiac dysfunction; TRPC; ER stress.;
TRPC1 and TRPC4 channels functionally interact with STIM1L to promote myogenesis and maintain fast repetitive Ca2Â + release in human myotubes
Keywords: Skeletal muscle; STIM1L; TRPC; Calcium channel; SOCE;
Increasing extracellular Ca2 + sensitizes TNF-alpha-induced vascular cell adhesion molecule-1 (VCAM-1) via a TRPC1/ERK1/2/NFκB-dependent pathway in human vascular endothelial cells
Keywords: CaSR; calcium-sensing receptor; CVDs; cardiovascular diseases; [Ca2 +]ex; extracellular Ca2 + concentration; ERK1/2; extracellular signal-regulated kinase 1/2; IκB; inhibitor of κB; IL; interleukin; [Ca2 +]i; intracellular calcium concentration; IKK;
Synaptopathic mechanisms of neurodegeneration and dementia: Insights from Huntington's disease
Keywords: 5-HT; 5-hydroxytryptamine; 7,8-DHF; 7,8-dihydroxyflavone; ACh; acetylcholine; AD; adenosine; ADL; activities of daily living; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPK; 5â²AMP-activated protein kinase; BDNF; brain-derived neurotro
The interaction domains of transient receptor potential canonical (TRPC)1/4 and TRPC1/5 heteromultimeric channels
Keywords: TRPC channel; Tetrameric structure; Förster Resonance Energy Transfer (FRET); TRPC; Transient receptor potential canonical; CCD; Coiled-coil domain; ARD; Ankyrin repeat domains; SESTD1; SEC14 and spectrin domains 1; aa; amino acid; PM; Plasma membrane; E
Muscarinic Receptor Induced Contractions of the Detrusor are Mediated by Activation of TRPC4 Channels
Keywords: urinary bladder; muscle contraction; transient receptor potential channels; acetylcholine; cholinergic agents; 2-APB; 2-aminoethoxydiphenyl borate; 4-DAMP; 1,1-dimethyl-4-diphenylacetoxypiperidinium; ACh; acetylcholine; ATP; adenosine triphosphate; BK; la
Modulatory influences of estradiol and other anorexigenic hormones on metabotropic, Gi/o-coupled receptor function in the hypothalamic control of energy homeostasis
Keywords: 2-AG; 2-arachidonoylglycerol; AgRP; agouti-related peptide; AMPK; AMP-activated protein kinase; ARC; hypothalamic arcuate nucleus; CRH; corticotropin-releasing hormone; DSI; depolarization-induced suppression of inhibition; ERK; extracellular signal-regul
Cardiovascular pharmacologyBroad-range TRP channel inhibitors (2-APB, flufenamic acid, SKF-96365) affect differently contraction of resistance and conduit femoral arteries of rat
Keywords: 2-APB; 2-aminoethoxydiphenyl borate; CRC; concentration-response curve; FFA; flufenamic acid; L-VDCC; L-type voltage-dependent Ca2+ channel; NMDG+; N-methyl-D-glucamine; SKF-96365; 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole; TRPC
The atypical 'b' splice variant of phospholipase Cβ1 promotes cardiac contractile dysfunction
Keywords: DGKζ; diacylglycerol kinase ζ; FS; fractional shortening; LVIDd; left ventricular internal diameter at diastole; LVIDs; left ventricular internal diameter at systole; LVPWd; left ventricular posterior wall thickness at diastole; LVPWs; left ventricular
TRPC1 regulates fMLP-stimulated migration and chemotaxis of neutrophil granulocytes
Keywords: DAG; diacylglycerol; fMLP; N-formyl-methionine-leucine-phenylalanine; FPR; N-formyl-methionine-leucine-phenylalanine receptor; IP3; inositol 1,4,5-trosphosphate; PLC; phospholipase C; ROCE; receptor operated calcium entry; SOCE; store operated calcium ent
Sex differences in the role of transient receptor potential (TRP) channels in endothelium-dependent vasorelaxation in porcine isolated coronary arteries
Keywords: A23187; calcium ionophore; ACA; 2-[3-(4-pentylphenyl)prop-2-enoylamino]benzoic acid; EDH; endothelium-derived hyperpolarization; H2O2; hydrogen peroxide; L-NAME; NG-nitro-L-arginine methyl ester; PCAs; porcine coronary arteries; Pyr3; ethyl 1-[4-(trichlor
Molecular determinants of TRPC1 regulation within ER-PM junctions
Keywords: TRPC; STIM1; Orai1; SOCE; ER-PM junctions; Lipid rafts; Caveolin;
Interaction of SiO2 nanoparticles with neuronal cells: Ionic mechanisms involved in the perturbation of calcium homeostasis
Keywords: [Ca2+]i; cytosolic free calcium concentration; DLS; dynamic light scattering; DMEM; Dulbecco's modified Eagle's medium; EGTA; ethylene glycol tetraacetic acid; ELS; electrophoretic light scattering; FBS; fetal bovine serum; GnRH; gonadotropin hormone rele
Proarrhythmic effect of sustained EPAC activation on TRPC3/4 in rat ventricular cardiomyocytes
Keywords: cAMP; 3â²,5â²-cyclic adenosine monophosphate; PKA; protein kinase A; EPAC; Exchange Protein directly Activated by Cyclic AMP; LTCC; L-type Ca2+ channel; NCX; Na+/Ca2+ exchanger; RyR; ryanodine receptor; SR; sarcoplasmic reticulum; TRPC; Transient Recept
FKBP25 and FKBP38 regulate non-capacitative calcium entry through TRPC6
Keywords: Cyps; cyclophilins; FKBPs; immunophilins; FKBD; FK506-binding domain; ER; rough endoplasmic reticulum; SERCA; sarco-endoplasmic Ca2+-ATPase; IP3Rs; inositol 1,4,5-trisphosphate receptors; IP3; inositol 1,4,5-trisphosphate; TRPC; transient receptor potenti
Silencing of PKC-α, TRPC1 or NF-κB expression attenuates cisplatin-induced ICAM-1 expression and endothelial dysfunction
Keywords: Cisplatin; PKC; NF-κB; TRPC; SOCE; ICAM; Endothelium
Growth Factor Independence-1 (Gfi1) Is Required for Pancreatic Acinar Unit Formation and Centroacinar Cell Differentiation
Keywords: Centroacinar Cells; Claudin 10; Growth Factor Independence-1 (Gfi1); BPL; Bauhinia purpurea lectin; BrdU; bromodeoxyuridine; CACs; centroacinar cells; DIG; digoxigenin; EM; electron micrographs; Gfi1; growth factor independence-1; PBS; phosphate-buffered
Regulation of hippocampal synaptic plasticity by BDNF
Keywords: 4E-BPs; eIF4E-binding proteins; 5-HT; 5-hydroxytryptamine; ADF; actin-depolymerising factor; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; AMPA receptors; Arc; activity-regulated cytoskeleton-associated protein; BDNF; brain-derived n
Wnt5a inhibits K+ currents in hippocampal synapses through nitric oxide production
Keywords: Wnt5a; wingless-type family member 5a; NMDA; N-methyl d-aspartic acid; NO; nitric oxide; 7-NI; 7-nitroindazole; ROR2; receptor tyrosine kinase-like orphan receptor 2; sFRP-2; soluble frizzled related protein 2; DVL; Disheveled; Wnt/PCP; Wnt/planar cell po
Heteromeric TRPC3 with TRPC1 formed via its ankyrin repeats regulates the resting cytosolic Ca2+ levels in skeletal muscle
Keywords: TRP; transient receptor potential; TRPC; canonical-type TRP; AR; ankyrin repeats; ECC; excitation-contraction coupling; DMD; Duchenne muscular dystrophy; 3D; three-dimensional; TRPC3; TRPC1; Skeletal muscle; Ankyrin repeat; Heteromerization;
TRPC6 participates in the regulation of cytosolic basal calcium concentration in murine resting platelets
Keywords: Non-IP; non-immunoprecipitated fraction; IP; immunoprecipitated fraction; input; unbiotinylated fraction; VSMCs; mesenteric artery vascular smooth muscle cells; TRPC; Calcium; Platelets; Hemostasis; Thrombosis;
Serotonin induces depolarization in lateral amygdala neurons by activation of TRPC-like current and inhibition of GIRK current depending on 5-HT2C receptor
Keywords: Lateral amygdala; Serotonin; TRPC; GIRK; PIP2; PI3-kinase;
Activation of canonical transient receptor potential channels preserves Ca2+ entry and endothelium-derived hyperpolarizing factor-mediated function in vitro in porcine coronary endothelial cells and coronary arteries under conditions of hyperkalemia
Keywords: 31.4; 34; ANOVA; analysis of variance; [Ca2+]i; intracellular Ca2+ concentration; EDHF; endothelium-derived hyperpolarizing factor; HTK; histidine-tryptophan-ketoglutarate; ILH; indomethacin, NG-nitro-L-arginine, and oxyhemoglobin; NO; nitric oxide; NPSS;
How ORAI and TRP channels interfere with each other: Interaction models and examples from the immune system and the skin
Keywords: ORAI1; STIM1; TRPC; T lymphocytes; keratinocytes; Melanocytes
20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol, a metabolite of ginseng, inhibits colon cancer growth by targeting TRPC channel-mediated calcium influx
Keywords: Calcium influx; Colon cancer; 20-GPPD; TRPC;
FKBP52 is involved in the regulation of SOCE channels in the human platelets and MEG 01 cells
Keywords: Cyps; cyclophilins; FKBPs; immunophilin; FKBP52; FK506 binding protein (52); ER; rough endoplasmic reticulum; SERCA2b; sarco-endoplasmic Ca2Â +-ATPase isotype 2b; IP3R II; inositol 1,4,5-trisphosphate receptor; TRPC; transient receptor potential channel;
mRNA expression of ion channels in GnRH neurons: Subtype-specific regulation by 17β-estradiol
Keywords: AHP; afterhyperpolarization; E2; 17β-estradiol; GnRH; gonadotropin-releasing hormone; GPR54; G protein-coupled receptor 54; HCN; hyperpolarization-activated cyclic nucleotide-gated; HVA; high voltage activated; LH; luteinizing hormone; POA; preoptic area
Neuroendocrine signalling: Natural variations on a Ca2+ theme
Keywords: AVP; arginine vasopressin; OT; oxytocin; SON; supraoptic nucleus; [Ca2+]i; cytosolic Ca2+ transients/increase; CPA; cyclopiazonic acid; TG; thapsigargin; CCCP; carbonyl cyanide 3-chlorophenylhydrazone; ER; endoplasmic reticulum; SERCA; sarcoendoplasmic re
Gs cascade regulates canonical transient receptor potential 5 (TRPC5) through cAMP mediated intracellular Ca2+ release and ion channel trafficking
Keywords: TRPC; Gs; Beta-adrenergic receptor; Isoproterenol; cAMP; Ca2+;
Inositol 1,4,5-trisphosphate receptors and pacemaker rhythms
Keywords: 2-APB; aminoethoxydiphenyl borate; CICR; Ca2+-induced Ca2+ release; ET-1; endothelinâ1; GPCR; G-protein coupled receptors; HCN4; the hyperpolarization-activated, cyclic nucleotide-gate cation channels 4; IP3R; inositol 1,4,5-trisphosphate receptor; PLC;