Coupling acidic organelles with the ER through Ca2+ microdomains at membrane contact sites

- Acidic Ca2+ stores and the ER are functionally connected through the Ca2+ mobilising messenger, NAADP.
- Acidic Ca2+ stores and the ER are physically connected by membrane contact sites.
- Ca2+ microdomains likely form at membrane contact sites between acidic Ca2+ stores and the ER to facilitate inter-organellar crosstalk.