کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10926178 1091777 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The ancient roots of calcium signalling evolutionary tree
ترجمه فارسی عنوان
ریشه های قدیمی از درخت تکاملی سیگنال کلسیم
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی

- Fundamental elements of cellular Ca2+ homeostasis are conserved from bacteria to human.
- These include Ca2+-pumps and exchangers, Ca2+ influx channels as well as some CaBPs, such as calmodulin, which all are present in prokaryotes.
- The Ca2+/calmodulin-activated protein phosphatase PP2B (calcineurin) is engaged in manifold signalling from different protozoa up to human.
- However, there is a discrepancy between overt InsP3 effects observed and the failure to identify InsP3R-type genomic sequences in some organisms. The recent focus on choanoflagellates as ancestors of metazoans calls for the extension of molecular biology data to cell physiology.
- Many data on Ca2+ signalling throughout evolution yield a quite consistent picture. The present issue of Cell Calcium presents an interim balance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Calcium - Volume 57, Issue 3, March 2015, Pages 123-132
نویسندگان
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