Modulation of L-type Ca2+ channel activity by neuronal nitric oxide synthase and myofilament Ca2+ sensitivity in cardiac myocytes from hypertensive rat

- LTCC is more vulnerable to Ca2+-dependent inactivation in hypertension.
- nNOS modulates LTCC via Ca2+-dependent mechanism in hypertension.
- nNOS modulation of LTCC is Ca2+-independent in healthy heart.
- Myofilament Ca2+ desensitization (Myo-Ca-Desen) modulates LTCC in cardiac myocyte.
- nNOS and Myo-Ca-Desen modulation of LTCC is absent at high rate.