Mitochondrial Ca2+ handling is crucial for generation of rhythmical Ca2+ waves in vascular interstitial cells from rabbit portal vein

- The role of mitochondria in Ca2+ wave generation was studied in interstitial cells.
- ATP synthase inhibitor, oligomycin, did not affect Ca2+ wave amplitude and frequency.
- Uncoupling agents FCCP and CCCP blocked Ca2+ waves with simultaneous [Ca2+]i increase.