Potentiation of the store-operated calcium entry (SOCE) induces phytohemagglutinin-activated Jurkat T cell apoptosis

- MDEB potentiates store-operated Ca2+ entry in various cancer cell lines.
- The action of MDEB is more specific than that of the generally used inhibitor 2-APB.
- MDEB has a strong stimulatory effect of PHA-mediated Ca2+ increase in Jurkat cells.
- MDEB increases apoptosis in fully activated Jurkat cells.
- MDEB may represent the first member of a new family of immunomodulators.