The mitochondrial permeability transition pore and its adaptive responses in tumor cells

- The mitochondrial permeability transition pore (PTP) is a key effector in the pathways to cell death.
- The PTP forms from F-ATP synthase and is regulated by several signaling pathways.
- Tumor cells desensitize the PTP to Ca2+ and reactive oxygen species increasing their resistance to death.
- The PTP is a target for anticancer chemotherapeutics.