Organellar mechanosensitive channels involved in hypo-osmoregulation in fission yeast

- Function of MscS-like (MSL) proteins, Msy1 and Msy2, in fission yeast is discussed.
- Both proteins are localized in the ER and involved in the hypo-osmotic shock response.
- Both proteins regulate Ca2+ mobilization in response to hypo-osmotic shock.
- Some of algal and plant MSL proteins exhibit distinct function and localization.
- Function and localization of eukaryotic MSL proteins have diverged during evolution.