Inositol 1,4,5 trisphosphate receptor 1 is a key player of human myoblast differentiation

- IP3R1 plays an important role during human myoblast differentiation.
- Expression of transcription factors MEF2 and myogenin decreased upon siIP3R1 treatment.
- Spontaneous calcium oscillations are impaired upon siIP3R1 treatment.
- Ca2+-dependent signaling pathways, NFAT and CamKII, are reduced upon siIP3R1 treatment.