Hydrogen sulphide triggers VEGF-induced intracellular Ca2+ signals in human endothelial cells but not in their immature progenitors

- We studied the pro-angiogenic Ca2+ signals induced by H2S in mature and immature endothelial cells.
- H2S induces InsP3-dependent Ca2+ release in Ea.hy926 cells, a surrogate of mature endothelial cells.
- H2S does not elicit any detectable Ca2+ signal in endothelial progenitor cells (EPCs).
- The blockade of H2S synthesis prevents the Ca2+ response to VEGF in Ea.hy926 cells, but not in EPCs.
- The blockade of H2S abrogates VEGF-induced angiogenesis in Ea.hy926 cells, but not in EPCs.