Regulation of endogenous and heterologous Ca2+ release-activated Ca2+ currents by pH

- ICRAC function depends on intra- and extracellular pH.
- Aspartic acids (D110/D112) in Orai1 contribute to the extracellular pH-dependence.
- Inhibition of Ca2+ influx by low extracellular pH is a general feature of ICRAC.
- Low pH in tumors and infection may thus contribute to dysfunctional Ca2+ signaling.