PPAR-γ agonists, mainly 15d-PGJ2, reduce eosinophil recruitment following allergen challenge

► PPAR-γ agonists has been raised to control eosinophil-mediated inflammatory diseases. ► 15d-PGJ2 and rosiglitazone reduced the eosinophil migration and eosinopoiesis. ► IgE was decreased only after the administration of 15d-PGJ2 due to B-cell inhibition. ► The IL-5, IL-33, IL-17, and IL-23 was decreased after PPAR-γ administration.