Keywords: Glial cells; Cyclopentenone prostaglandins; Peroxisome proliferator-activated receptor-γ (PPARγ); C6-glioma cells; BrdU; bromodeoxyuridine; cyPGs; cyclopentenone prostaglandins; PG; prostaglandin; PPAR; peroxisome proliferator-activated receptor; LPS; l
مقالات ISI (ترجمه نشده)
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Keywords: RA; rheumatoid arthritis; RF; rheumatoid factor; ACPA; anti-citrullinated protein antibodies; AA; arachidonic acid; PG; prostaglandins; LT; leukotrienes; TX; thromboxanes; LX; lipoxins; NSAID; non steroidal anti-inflammatory drugs; COXIB; COX-2 selective
Keywords: ACS; Acyl-CoA synthetase; ARE/EpRE; Antioxidant/electrophile response element; Bcl-2; B-cell lymphoma 2; BMI; Body mass index; BSP; Broccoli sprout powder; CAT; Catalase; C/EBP; CCAAT/enhancer-binding protein; CD36; CD36 molecule/thrombospondin receptor;
Keywords: 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; ARE; antioxidant response element; COX; cyclooxygenase; DAMP; damage-associated molecular pattern; DC; dendritic cell; EC; epoxycyclopentenone; EI; epoxyisoprostane; ICAM; intercellular adhesion molecule; IFN-Î
Keywords: Diethylnitrosamine; Alkenal/one oxidoreductase; Carcinogen detoxification enzymes; 4-Hidroxynonenal; Tumor marker; HCC; hepatocellular carcinoma; DEN; diethylnitrosamine; S&F; Solt and Farber model; LTB4; leukotriene B4; PGE2; prostaglandin E2; 15d-PGJ2;
Keywords: 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; 4-HNE; 4-hydroxynonenal; bt-15d-PGJ2; biotin 15-deoxy-Î12,14-prostaglandin J2; BD-15d-PGJ2; BODIPY FL-15-deoxy-Î12,14-prostaglandin J2; DNA; deoxyribonucleic acid; DNPH; dinitrophenylhydrazine; Ep; electrophi
Keywords: 4-HNE; 4-hydroxynonenal; 15d-PGJ2; 15-deoxy-â12,14-prostaglandin J2; AP-1; activator protein-1; As3 +; trivalent arsenite; α-SMA; a-smooth muscle actin; ARE; antioxidant response element; ATRA; all-trans retinoic acid; BDL; bile duct ligation; BHMT; b
Keywords: Macrophage; dendritic cell; lipid; nuclear receptor; retinoid X receptor; retinoic acid receptor; peroxisome proliferator-associated receptor; liver X receptor; vitamin D receptor; rheumatoid arthritis; inflammatory bowel disease; systemic lupus erythemat
Ubiquitination and SUMOylation in the chronic inflammatory tumor microenvironment
Keywords: Inflammation-associated cancer; Ubiquitin-proteasome system (UPS); Small ubiquitin-like modifier (SUMO); Tumor microenvironment; Cytokine profile; Transcription factors; 15d-PGJ2; 15-Deoxy-Delta-12,14-prostaglandin J2; AR; androgen receptor; Ala; alanine;
A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis
Keywords: ASK1; apoptosis signal regulating kinase 1; Cul3; cullin 3; DEF; dimethylfumarate; DEM; diethylmaleate; 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; FBS; fetal bovine serum; 5-HI; 5-hydroxyoxindole derivative; HO-1; heme oxygenase-1; iNOS; inducible NO sy
Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair
Keywords: 15d-PGJ2; 15-deoxy-D12, 14prostaglandin J2; 15(S)-HETE; 15(S)-hydroxyeicosatetraenoic acid; ADP; adenosine diphosphate; AGE; advanced glycan end product; AMPA; α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid; ARE; antioxidant response element; AS; a
Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes
Keywords: 15d-PGJ2; 15-deoxy-delta-12,14-prostaglandin J2; 4HNE; 4-hydroxynonenal; AGA; androgenic alopecia; NAC; N-acetyl-cysteine; PBS; phosphate buffered saline; PGD2; prostaglandin D2; PGE2; prostaglandin E2;
Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells
Keywords: CBS; cystathionine β-synthase; CSE; cystathionine γ-lyase; Drp1; dynamin-related protein 1; 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; ERK; extracellular signal-regulated kinase; G protein; GTP-binding protein; GC; guanylate cyclase; GDP; guanosine 5'
15-Deoxy-Î12,14-prostaglandin J2 induced neurotoxicity via suppressing phosphoinositide 3-kinase
Keywords: 15-Deoxy-Î12,14-prostaglandin J2; Phosphoinositide 3-kinase; Neurotoxicity; Cerebral cortex; Hippocampus; Memory retrieval; 15d-PGJ2; 15-Deoxy-Î12,14-prostaglandin J2; CRTH2; Chemoattractant receptor-homologous molecule expressed on T-helper type 2 ce
Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides
Keywords: Electrophilic signaling; 8-Nitro-cGMP; NO; Redox signaling; 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; ERK; extracellular signal-regulated kinase; GSH; glutathione; GST; glutathione S-transferase; HNE; 4-hydroxy-2-nonenal; iNOS; inducible type of NO syn
PPARγ signaling and emerging opportunities for improved therapeutics
Keywords: PPARγ; peroxisome proliferator-activated receptor gamma; TZD; thiazolidinedione; T2DM; type 2 diabetes mellitus; RGZ; rosiglitazone; 15d-PGJ2; 15-deoxy-D12,14-prostanglandin J2; PGC-1α; PPARγ co-activator-1α; RXR; retinoid X receptor; PPRE; peroxisome
PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease
Keywords: PPARγ; peroxisome proliferation-activated receptor gamma; 15D-PGJ2; 15-deoxy-Î12,14-Prostaglandin J2; TZDs; thiazolidinediones; CNS; central nervous system; WAT; white adipose tissue; BAT; brown adipose tissue; SRC; steroid receptor coactivator; CBP; CR
Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death
Keywords: 15d-PGJ2; Chemotherapy; PI3K/Akt axis; Peroxisome proliferator-activated-receptor γ; Pro-survival signalling; ROS; Tumour protein p53;
Inhibitory effects of PPARγ ligands on TGF-β1-induced CTGF expression in cat corneal fibroblasts
Keywords: Rosiglitazone; Troglitazone; 15d-PGJ2; JNK; p38 MAPK; ERK; AKT; CTGF; connective tissue growth factor; CCN; cyr61, ctgf, neuroblastoma over-expressed gene; Nov; neuroblastoma over-expressed gene; ECM; extracellular matrix; PRK; photorefractive keratectomy
A ground state of PPARγ activity and expression is required for appropriate neural differentiation of hESCs
Keywords: 15d-PGJ2; Human embryonic stem cells; Neural differentiation; Pioglitazone; PPARγ
Close teamwork between Nrf2 and peroxiredoxins 1 and 6 for the regulation of prostaglandin D2 and E2 production in macrophages in acute inflammation
Keywords: AA; arachidonic acid; AP-1; activator protein-1; ARE; antioxidant-response element; BMDM; bone marrow-derived macrophage; COX-2; cyclooxygenase-2; DEX; dexamethasone; 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; ERK2; extracellular-regulated kinase 2; GST
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) promotes apoptosis of HBx-positive liver cells
Keywords: 15d-PGJ2; HBx; Liver cell; Apoptosis
15-deoxy-Δ12,14-prostaglandin J2 reduces albumin-induced arthritis in temporomandibular joint of rats
Keywords: Temporomandibular joint; Inflammation; 15d-PGJ2
15-deoxy-Î12,14-PGJ2 promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis
Keywords: Cardiomyocytes; TNFα; 15d-PGJ2; Apoptosis; PGD2 receptor;
15d-PGJ2 decreases PGE2 synthesis in HBx-positive liver cells by interfering EGR1 binding to mPGES-1 promoter
Keywords: Early growth response 1 (EGR1); Microsomal prostaglandin E synthase 1 (mPGES-1); Promoter; HBV X protein (HBx); Hepatocyte; HBV; Hepatitis B virus; HCC; hepatocellular carcinoma; HBx; HBV X protein; PGE2; prostaglandin E2; COX; cyclooxygenase; mPGES-1; mi
15-Deoxy-Î12,14-prostaglandin J2 induces PPARγ- and p53-independent apoptosis in rabbit synovial cells
Keywords: 15d-PGJ2; PPARγ; Synovial; Apoptosis; p53; Caspase;
Short communicationPossible involvement of aiPLA2 in the phosphatidylserine-containing liposomes induced production of PGE2 and PGD2 in microglia
Keywords: Microglia; Phosphatidylserine liposomes; PGE2; PGD2; 15d-PGJ2; aiPLA2;
15-Deoxy-Î12,14-prostaglandin J2 inhibits IL-13 production in T cells via an NF-κB-dependent mechanism
Keywords: IL-13; T cells; 15d-PGJ2; NF-κB;
Low doses of 15d-PGJ2 induce osteoblast activity in a PPAR-gamma independent manner
Keywords: 15d-PGJ2; Inflammation; Osteoblast; Bone; PPAR-gamma;
Identification of 15d-PGJ2 as an antagonist of farnesoid X receptor: Molecular modeling with biological evaluation
Keywords: 15d-PGJ2; 15-deoxy-Î12,14-PGJ2; AA; arachidonic acid; PPARγ; peroxisome proliferator-activated receptor γ; FXR; farnesoid X receptor; SPR; surface plasmon resonance; FQ; fluorescence quenching; HTRF; homo time-resolved fluorescence; BSEP; bile-salt exp
Stimulation of mitochondrial oxidative capacity in white fat independent of UCP1: A key to lean phenotype
Keywords: ACC; acetyl-CoA carboxylase; AMPK; AMP-activated protein kinase; aP2-Ucp1 mice; transgenic mice expressing UCP1 gene from the aP2 gene promoter; AA; arachidonic acid; ATM; adipose tissue macrophages; BAT; brown adipose tissue; BCAA; branched-chain amino a
Tumor apoptosis in prostate cancer by PGD2 and its metabolite 15d-PGJ2 in murine model
Keywords: 15d-PGJ2; Apoptosis; Prostate cancer
15d-PGJ2-loaded in nanocapsules enhance the antinociceptive properties into rat temporomandibular hypernociception
Keywords: 15d-PGJ2; PPAR-gamma; Nociception; Temporomandibular joint; Inflammation;
N-3 PUFAs attenuate ischemia/reperfusion induced intestinal barrier injury by activating I-FABP-PPARγ pathway
Keywords: n-3 PUFAs; PPARγ; 15d-PGJ2; Occludin; I-FABPn-3 PUFAs, n-3 polyunsaturated fatty acids; I-FABP, Intestinal fatty acid binding protein; I/R, Ischemia and reperfusion; PPARγ, Peroxisome proliferator-activated receptor γ; TJ, Tight junction
PPAR-γ agonists, mainly 15d-PGJ2, reduce eosinophil recruitment following allergen challenge
Keywords: PPAR-γ; 15d-PGJ2; Eosinophils; Inflammation;
High sodium butyrate levels induce MDR1 activation in colorectal cells: Impact of 15-deoxy-Δ12,14-prostaglandin J2 on the resistance to saquinavir
Keywords: P-glycoprotein; MDR1; Sodium butyrate; 15d-PGJ2; HIV; Saquinavir
Is targeting eNOS a key mechanistic insight of cardiovascular defensive potentials of statins?
Keywords: AFCAPS/TexCAPS; Air Force/Texas Coronary Atherosclerosis Prevention Study; ARMYDA; Atorvastatin for Reduction of MYocardial Damage during Angioplasty; ASCOT-LLA; The Anglo-Scandinavian Cardiac Outcomes Trial- Lipid-Lowering Arm; AURORA; A Study to Evaluat
Nitro-fatty acids as novel electrophilic ligands for peroxisome proliferator-activated receptors
Keywords: PPAR; peroxisome proliferator-activated receptor; NR; nuclear receptor; RXR; retinoid X receptor; FA-NO2; nitro-fatty acid(s); PPRE; peroxisome proliferator response element; DBD; DNA binding domain; LBD; ligand binding domain; PUFA; long-chain polyunsatu
Long-term CFTR inhibition modulates 15d-prostaglandin J2 in human pulmonary cells
Keywords: CFTR inhibitors; Cyclooxygenases; PGD2; 15d-PGJ2; Inflammatory cytokines
Validation of the multiple sensor mechanism of the Keap1-Nrf2 system
Keywords: tBHQ; tert-butylhydroquinone; BTB; broad complex-tramtrack-bric a brad; CDDO-Im; 2-cyano-3,12 dioxooleana-1,9 diene-28-imidazolide; CDNB; 1-chloro-2,4-dinitrobenzene; DEM; diethylmaleate; DMF; dimethylfumarate; Gclc; glutamate-cysteine ligase catalytic su
Inflammation-related gene expression by lipid oxidation-derived products in the progression of atherosclerosis
Keywords: 7α-OH; 7α-hydroxycholesterol; 7-K; 7-ketocholesterol; 9-ONC; 9-oxononanoyl cholesterol; 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; α-EPOX; 5α,6α-epoxycholesterol; AP-1; activator protein-1; ARE; antioxidant-responsive element; ATF; activating trans
Electrophilic eicosanoids: Signaling and targets
Keywords: Cyclopentenone prostaglandins; Protein modification; Michael addition; Resolution of inflammation; Protein cross-linking; 15d-PGJ2
Sustained expression of lipocalin-type prostaglandin D synthase in the antisense direction positively regulates adipogenesis in cloned cultured preadipocytes
Keywords: PG; prostaglandin; L-PGDS; lipocalin-type PGD synthase; COX; cyclooxygenase; 15d-PGJ2; 15-deoxy- Π12,14-prostaglandin J2; PPARγ; peroxisome proliferator-activated receptor γ; G418; geneticin; FBS; fetal bovine serum; RT-PCR; reverse transcriptase-poly
In vitro effects of peroxisome proliferator-activated receptor-γ ligands on gene expression in lipopolysaccharide-induced endometrial and endometriotic stromal cells
Keywords: Endometriosis; inflammation; ESCs; PPAR-γ; rosiglitazone; 15d-PGJ2;
Development of enzyme-linked immunosorbent assay for Î12-prostaglandin J2 and its application to the measurement of the endogenous product generated by cultured adipocytes during the maturation phase
Keywords: PPARγ; peroxisome proliferator-activated receptor γ; PG; prostaglandin; 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; COX; cyclooxygenase; L-PGDS; lipocalin-type prostaglandin D synthase; ELISA; enzyme-linked immunosorbent assay; DME-HEPES; Dulbecco's mo
PPARγ stabilizes HO-1 mRNA in monocytes/macrophages which affects IFN-β expression
Keywords: 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; CRE; causes recombination; CO; carbon monoxide; CHX; cycloheximide; d/n; dominant negative; DPI; diphenyliodonium; HE; hydroethidine; HO-1; heme oxygenase-1; LPS; lipopolysaccharide; LysM; lysozyme M; mac; macr
15-Deoxy-Î12,14-prostaglandin J2 interferes inducible synthesis of prostaglandins E2 and F2α that suppress subsequent adipogenesis program in cultured preadipocytes
Keywords: PG; prostaglandin; PMA; phorbol 12-myristate 13-acetate; 15d-PGJ2; 15-deoxy-Î12,14-PGJ2; PPARγ; peroxisome proliferator-activated receptor γ; COX; cyclooxygenase; PDTC; pyrrolidinedithiocarbamate; NF-κB; nuclear factor-kappa B; L-PGDS; lipocalin-type
Assessing bioenergetic function in response to oxidative stress by metabolic profiling
Keywords: 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; 2-DG; 2-deoxy-d-glucose; AUC; area under the curve; Deta NO; Deta NONOate, (Z)-1-[2-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate; DMNQ; 2,3-dimethoxy-1,4-napthoquinone; DPI; diphenyleneiodoni
Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components
Keywords: 15d-PGJ2; 15-deoxy-Î12,14 prostaglandin J2; 5-ASA; 5-aminosalicylic acid; c9, t11; cis-9 trans-11; CLA; conjugated linoleic acid; DHA; docosahexaenoic acid; EPA; eicosapentaenoic acid; IgA; immunoglobulin A; IL; interleukin; PPARγ; peroxisome proliferat
Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1
Keywords: 15d-PGJ2; Mitochondrial fusion; Mitochondrial fission; OPA1; Mitofusin; Ubiquitination