کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10953821 | 1097813 | 2012 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Is targeting eNOS a key mechanistic insight of cardiovascular defensive potentials of statins?
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کلمات کلیدی
WOSCOPSAFCAPS/TexCAPSLOX-1SR-B1SREBP15d-PGJ2hsCRPGGPPHPStetrahydrobiopterinBH4HMG-CoAEPCseNOSPPARPI3KEDRFPDK-1Air Force/Texas Coronary Atherosclerosis Prevention StudyFPPRho-kinaseHeart Protection Study3-phosphoinositide-dependent kinase-1 - 3-فسفوئوزیتید وابسته به کیناز-13-Hydroxy-3-methylglutaryl-CoA - 3-هیدروکسی 3-متیل گلوتاریل-CoAPKB/AKT - PKB / AKTROS - ROSVascular endothelial dysfunction - اختلال اندوتلیال عروقیStatins - استاتین Care - اهمیت دادنEcto-5′-nucleotidase - اکتو -5'-نوکلئوتیدازVed - توسطCardiovascular protection - حفاظت قلب و عروقProsper - رونقEndothelial progenitor cells - سلول های پیش ساز اندوتلیالendothelial nitric oxide synthase - سنتاز اکسید نیتریک اندوتلیالAURORA - شفق قطبیfarnesyl pyrophosphate - فارسیل پیرو فسفاتendothelium-derived relaxing factor - فاکتور آرامش بخش اندوتلیومLow-density lipoprotein - لیپوپروتئین کم چگالی یا الدیال LDL - لیپوپروتئین کم چگالی(کلسترول بد)Lipid - لیپیدJUPITER - مشتری، هرمزScandinavian Simvastatin Survival Study - مطالعه بقاء سیمواستاتین اسکاندیناویNitric oxide - نیتریک اکسیدsterol regulatory element binding protein - پروتئین اتصال دهنده عصاره استرولprotein kinase B - پروتئین کیناز Bgeranylgeranyl pyrophosphate - ژرینیل گرانیل پیرو فسفاتcaveolin-1 - کائولین-1Cholesterol and Recurrent Events - کلسترول و رویدادهای مکررCorona - کوروناReactive oxygen species - گونههای فعال اکسیژنperoxisome proliferator-activated receptor - گیرنده فعال فعال پروکسیوم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Statins are widely used in the treatment of dyslipidemia and associated cardiovascular abnormalities including atherosclerosis, hypertension and coronary heart disease. Needless to mention, statins have cholesterol-lowering effects by means of inhibiting 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, a rate-limiting enzyme of cholesterol biosynthesis. Besides cholesterol-lowering effects, statins possess pleiotropic anti-inflammatory, anti-oxidant, anti-platelet and anti-fibrotic properties, which may additionally play imperative roles in statins-mediated cardiovascular protection. However, the precise mechanisms involved in the cardiovascular defensive potential of statins have not completely been elucidated. Intriguingly, a considerable number of studies demonstrated the potential modulatory role of statins on endothelial nitric oxide synthase (eNOS), a key enzyme involved in the regulation of cardiovascular function by generating endothelium-derived relaxing factor (often represented 'nitric oxide'). Worthy of note is that vascular generation of nitric oxide has beneficial anti-inflammatory, anti-platelet and vasodilatory actions. The upregulation of eNOS by statins is mediated through inhibition of synthesis of isoprenoids and subsequent prevention of isoprenylation of small GTPase Rho, whereas statin-induced activation of eNOS is mediated through activation of phosphotidylinositol-3-kinase (PI3K)/protein kinase B (PKB/Akt) signals. Additionally, statins enhance eNOS activation by abrogating caveolin-1 expression in vascular endothelium. In light of this view-point, we suggest in this review that eNOS upregulation and activation, in part, could play a fundamental role in the cardiovascular defensive potential of statins. The eNOS modulatory role of statins may have an imperative influence on the functional regulation of cardiovascular system and may offer new perspectives for the better use of statins in ameliorating cardiovascular disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular and Cellular Cardiology - Volume 52, Issue 1, January 2012, Pages 83-92
Journal: Journal of Molecular and Cellular Cardiology - Volume 52, Issue 1, January 2012, Pages 83-92
نویسندگان
Pitchai Balakumar, Sonam Kathuria, Gaurav Taneja, Sanjeev Kalra, Nanjaian Mahadevan,