Keywords: FPPS; farnesyl pyrophosphate synthase; MIR; myocardial ischemia/reperfusion; HR; hyproxia/reoxygenation; ROS; reactive oxygen species; FPP; arnesyl pyrophosphate; GGPP; geranylgeranyl pyrophosphate; SHR; spontaneously hypertensive rats; DMEM; Dulbecco's m
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Keywords: CCD; carotenoid cleavage dioxygenase; CHYB; β-carotene hydroxylase; DAFB; days after full bloom; DMAPP; dimethylallyl diphosphate; FPP; farnesyl diphosphate; FPPS; farnesyl diphosphate synthase; FW; fresh weight; GGPP; geranylgeranyl diphosphate; GGPS; g
Keywords: Atorvastatin; γ-tocotrienol; Mevalonate pathway; Multidrug resistance; MDR; multidrug resistance; HMG-CoA; 3-hydroxy-3-methylglutaryl-coenzyme A; FPP; farnesyl pyrophosphate; GGPP; geranylgeranyl pyrophosphate; RI; Resistance index; IC50; half-maximal in
Keywords: Farnesol; Isoprenoid biosynthesis; Methylerythritol phosphate; Mevalonate; Plants; Protein prenylation; DX; 1-deoxy-d-xylulose; FOS; fosmidomycin; FPP; farnesyl diphosphate; GGPP; geranylgeranyl diphosphate; HMGR; 3-hydroxy-3-methylglutaryl coenzyme A red
Keywords: 2D; two-dimensional; AD; Alzheimer's disease; APP; amyloid precursor protein; FPP; farnesyl pyrophosphate; GGPP; geranylgeranyl pyrophosphate; GGT; geranylgeranyl transferase; GGTI; GGT inhibitor; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic aci
Keywords: Cancer stem-like cells; Mevalonate cascade; Ras; Rho; Stemness; Statins; Yap; ACAT; acetoacetyl-CoA transferase; acetyl-CoA; acetyl-coenzyme A; Arp2/3; actin-related protein 2/3 (actin polymerizing complex); BPs; bisphosphonates; CAMs; cell adhesion molec
Keywords: DTCs; diterpene cyclases; DTSs; diterpene synthases; KgTS; terpentetriene synthase from Kitasatospora griseola; SsSS; sclareol synthase from Salvia sclarea; GGPP; (E,E,E)-geranylgeranyl diphosphate; NNPP; (Z,Z,Z)-nerylneryl diphosphate; GGPS; (E,E,E)-gera
Keywords: Isoprenoids; Metabolic engineering; Protein engineering; Combinatorial biosynthesis; Cytochrome P450; TPS; terpene synthase; GPP; geranyl diphosphate; DMAPP; dimethylallyl diphosphate; IPP; isopentenyl diphosphate; FPP; farnesyl diphosphate; GGPP; geranyl
Keywords: 4CL; 4-coumaroyl CoA ligase; ADME/T; absorption, distribution, metabolism, excretion (and toxicity); BIA; benzylisoquinoline alkaloid; C4H; cinnamate 4-hydroxylase; CoA; coenzyme A; CRISPR/Cas9; clustered regulatory interspaced short palindromic repeat/CR
Keywords: SQS; squalene synthase; hSQS; human squalene synthase; CrtN; dehydrosqualene desaturase; CrtM; dehydrosqualene synthase; CrtI; phytoene desaturase; CrtB; phytoene synthase; FPP; farnesyl diphosphate; GGPP; geranylgeranyl diphosphate; PSPP; presqualene dip
Keywords: ABA; phytohormones abscisic acid; MYB340; Myb-related protein 340; FBP2; floral binding protein 2; PKS1; phytochrome kinase substrate 1; PSY; phytoene synthase; GGPP; geranylgeranyl pyrophosphate synthase; PDS; phytoene desaturase; Z-ISO; ζ-carotene isom
Keywords: Maize lines; Carotenoids; Heterosis; Total antioxidant capacity; ABA; abscisic acid; ABTS; 2,2-azino-bis/3-ethil-benothiazoline-6-sulfonic acid; ANOVA; analysis of variance; BP; best parent; BPH; best parent heterosis; CRTISO; carotene isomerase; DPPH; 2,
Keywords: aa; amino acid; KS; ent-kaurene synthase; KSL; KS-like; RcKS(L); castor bean (Ricinus communis) KS(L) Euphorbiaceae; AtKS; Arabidopsis thaliana KS Cruciferae; CPP; copalyl diphosphate; CPS; CPP synthase; GC-MS; gas chromatography with mass spectrometric
Keywords: ABC; ATP-binding cassette; ADH; alcohol dehydrogenase; ADR; adrenodoxin reductase; ADX; adrenodoxin; ARE2; sterol acyltransferase; ARV1; mediator of sterol homeostasis; BTS1; GGPP synthase; CPR; cytochrome P450 reductase; CRT; carotenogenic (genes); CYP;
Keywords: AACT; acetoacetyl-CoA thiolase; ADP; adenosine diphosphate; APC; allophycocyanin; ATP; adenosine triphosphate; BChl; bacteriochlorophyll; CAR; carotenoid; CDP-ME2P; 4-(citidine 5â²-diphospho)-2-C-methyl-d-erythritol; Chl; chlorophyll; CHYβ; β-hydroxyla
Biosynthetic machinery for C25,C25-diether archaeal lipids from the hyperthermophilic archaeon Aeropyrum pernix
Keywords: Archaea; Archaeal lipid; Hyperthermophile; Isoprenoid; Phospholipid; Prenyltransferase; DGFGP; digeranylfarnesylglyceryl phosphate; DGGGP; digeranylgeranylglyceryl phosphate; DGFGP-glycerol; digeranylfarnesylglyceryl phosphoglycerol; DMAPP; dimethylallyl
Quantitative determination of a potent geranylgeranyl diphosphate synthase inhibitor using LC-MS/MS: Derivatization and application
Keywords: Geranylgeranyl diphosphate synthase inhibitor; GGDP; GGPP; LC-MS/MS;
Engineering metabolic pathways in Amycolatopsis japonicum for the optimization of the precursor supply for heterologous brasilicardin congeners production
Keywords: Norcardia terpenica IFM0406; Mevalonate pathway; Isoprenoids; Prenyltransferases; Aact; acetoacetyl CoA thiolase; BraA; brasilicardin A; BraB; brasilicardin B; BraC; brasilicardin C; BraD; brasilicardin D; BraC-agl; brasilicardin C aglycon; BraD-agl; bras
Proteome analysis provides insight into the regulation of bioactive metabolites in Hericium erinaceus
Keywords: DEP; differentially expressed protein; GGPP; geranylgeranyldiphosphate; TS; taxadiene synthase; ent-CPS; ent-copalyl diphosphate synthase; ent-KS; ent-kaurene synthase; PKS; polyketide synthase; Hericium erinaceus; Bioactive metabolites; Fruiting body; Pr
Accumulation of carotenoids in a novel citrus cultivar 'Seinannohikari' during the fruit maturation
Keywords: Citrus; β-Cryptoxanthin; Flavedo; Gene expression; Juice sacs; GGPP; geranylgeranyl diphosphate; CitPSY; phytoene synthase; CitPDS; phytoene desaturase; CitZDS; ζ-carotene desaturase; CitCRTISO; ζ-carotene isomerase; CitLCYb; lycopene β-cyclase; CitLC
Effect of exogenous auxin on aroma volatiles of cherry tomato (Solanum lycopersicum L.) fruit during postharvest ripening
Keywords: AADC; aromatic amino acid decarboxylase; ADH; alcohol dehydrogenase; BCAT; branched-chain aminotransferases; CCD; carotenoid cleavage dioxygenases; DAHP; 3-deoxy-d-arabino-heptulosonate 7-phosphate; DMAPP; dimethylallyl diphosphate; F-6-P; fructose-6-phos
Systemic or Forebrain Neuron-Specific Deficiency of Geranylgeranyltransferase-1 Impairs Synaptic Plasticity and Reduces Dendritic Spine Density
Keywords: ALS; amyotrophic lateral sclerosis; aCSF; artificial cerebrospinal fluid; AD; Alzheimer's disease; ANOVA; analysis of variance; AO; apical oblique; BS; basal shaft; CaMKII α; Ca2+/calmodulin-dependent protein kinase; CNS; central nervous system; Cre+;
The colourless carotenoids phytoene and phytofluene: From dietary sources to their usefulness for the functional foods and nutricosmetics industries
Keywords: ABA; abscisic acid; ABTS; 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid; ARE; antioxidant response element; BCAR; β-carotene; BHT; butylated hydroxytoluene; CD; control diet; CD36; cluster of differentiation 36; c.d.b.; conjugated double bonds; COX
Diverse responses of tanshinone biosynthesis to biotic and abiotic elicitors in hairy root cultures of Salvia miltiorrhiza and Salvia castanea Diels f. tomentosa
Keywords: AACT; acetyl-CoA C-acetyltransferase; CPS; copalyl diphosphate synthase; CT; cryptotanshinone; CYPs; cytochromes P450; DMAPP; dimethylallyl diphosphate; DT-I; dihydrotanshinone I; DXR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; DXS; 1-deoxy-d-xylulo
Trauma system in Greece: Quo Vadis?
Keywords: TC; trauma centre; MTC; major trauma centre; RTI; road traffic incident; EMS; emergency medical service; EKAB; ethniko kentro amesis boitheias (Hellenic EMS); NHS; National Health System; ESY; ethniko systima ygeias (Hellenic NHS); ALS; advanced life supp
RNA interference of NtNCED3 reduces drought tolerance and impairs plant growth through feedback regulation of isoprenoids in Nicotiana tabacum
Keywords: ABA; abscisic acid; ABRE; abscisic acid responsive element; APX; ascorbate peroxidase; CAT; catalase; Ci; intercellular CO2 concentration; CYP71D16; cytochrome P450 hydroxylase; CYC; cembratrien-ol synthase; NCED; 9-cis-epoxycarotenoid dioxygenase; ERE; e
Phototrophic production of heterologous diterpenoids and a hydroxy-functionalized derivative from Chlamydomonas reinhardtii
Keywords: cdm; cell dry mass; IPP; isopentenyl pyrophosphate; DMAPP; dimethylallyl pyrophosphate; FPPs; farnesyl pyrophosphate (synthase); GGPP; geranylgeranyl pyrophosphate; TAP; Tris acetate phosphate medium; YFP; mVenus yellow fluorescent protein; CFP; mCerulean
Ras inhibitor S-trans, trans-farnesylthiosalicylic acid enhances spatial memory and hippocampal long-term potentiation via up-regulation of NMDA receptor
Keywords: S-trans; Trans-farnesylthiosalicylic acid (FTS); Spatial cognition; Long-term potentiation (LTP); NMDA receptor; Hippocampus; ACSF; artificial cerebral spinal fluid; ANOVA; analyses of variance; CaMKII; Ca2+/calmodulin-kinase II; CREB; cAMP response eleme
Tailored carbon partitioning for phototrophic production of (E)-α-bisabolene from the green microalga Chlamydomonas reinhardtii
Keywords: AgBs; Abies grandis bisabolene synthase; amiRNA; artificial micro ribonucleic acid; CDW; cell dry weight;; IPP; isopentenyl pyrophosphate; DMAPP; dimethylallyl pyrophosphate; FPP; farnesyl pyrophosphate; GGPP; geranylgeranyl pyrophosphate; TAP; Tris Aceta
Regular articleEnhanced synthesis of Coenzyme Q10 by reducing the competitive production of carotenoids in Rhodobacter sphaeroides
Keywords: R.sphaeroides; Rhodobacter sphaeroides; CoQ10; Coenzyme Q10; GGPP; geranylgeranyl diphosphate; MEP; 2-C-methy-d-erythritol 4-phosphate; crt; carotenoids synthesis; E. coli; Escherichia coli; Coenzyme Q10; Carotenoids; Geranylgeranyl diphosphate; ppsR; Rho
Floral scent: Regulation and role of MYB transcription factors
Keywords: ACP; acyl-acyl carrier protein; AOS; allege oxide synthase; DMAPP; dimethyl allyl diphosphate; FPP; farnesyl pyrophosphate; FPPS; farnesyl pyrophosphate synthase; GPP; geranyl diphosphate; GGPP; geranylgeranyl diphosphate farnesyl diphosphate; IPP; isop
Identification of enzymes involved in the mevalonate pathway of Flavobacterium johnsoniae
Keywords: Mevalonate pathway; Isoprenoid; Mevalonate kinase; Phosphomevalonate kinase; Diphosphomevalonate decarboxylase; BMD; bisphosphomevalonate decarboxylase; DMD; diphosphomevalonate decarboxylase; GGPP; geranylgeranyl diphosphate; IP; isopentenyl phosphate; I
Research PaperMolecular cloning and functional characterization of a monoterpene synthase isolated from the aromatic wild shrub Thymus albicans
Keywords: DAB; 3,3â²-Diaminobenzidine; DTT; Dithiothreitol; cDNA; Complementary DNA; EO; Essential oil; FPP; Farnesyl diphosphate; GC; Gas Chromatography; GC-MS; Gas Chromatography coupled with Mass Spectrometry; GGPP; Geranyl geranyldiphosphate; GPP; Geranyl di
Two Eucommia farnesyl diphosphate synthases exhibit distinct enzymatic properties leading to end product preferences
Keywords: Eucommia; Farnesyl diphosphate synthase; Metal ion dependency; Prenyltransferase; Substrate inhibition; CLD; chain length determination; DMAPP; dimethylallyl diphosphate; DOPE; discrete optimized protein energy; FPP; farnesyl diphosphate; FPS; farnesyl di
Simvastatin inhibits CD44 fragmentation in chondrocytes
Keywords: Chondrocyte; Pericellular matrix; Statin; CD44; Lipid raft; ADAM10; HA; hyaluronan; OA; osteoarthritis; OSM; Oncostatin M; BAC; bovine articular chondrocytes; HAC; human articular chondrocytes; MT1-MMP; membrane type I metalloproteinase; ICD; intracellula
ABA accumulation in water-stressed Citrus roots does not rely on carotenoid content in this organ
Keywords: ABA; abscisic acid; ABA-GE; ABA-glycosylester; AAO3; abscisic aldehyde oxidase; AOG; ABA O-glycosyl transferase; DHJA; dehydrojasmonic acid; DPA; dihydrophaseic acid; GGPP; geranylgeranyldiphosphate; JA-Ile; jasmonoyl-isoleucine; NCED; 9-cis-epoxycaroteno
Isoprenoid generating systems in plants - A handy toolbox how to assess contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthetic process
Keywords: Ac-CoA; acetyl CoA; AACT; AcAC-CoA thiolase; CLM; clomazone (2-[(2-chlorophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone); DMAPP; dimethylallyl diphosphate; DMNT; (3E)-4,8-dimethyl-1,3,7-nonatriene; DOXP; deoxyxylulose phosphate; DX; 1-deoxy-d-xylulose; DXK
Simvastatin induces insulin resistance in L6 skeletal muscle myotubes by suppressing insulin signaling, GLUT4 expression and GSK-3β phosphorylation
Keywords: Simvastatin; Glucose uptake; Glucose transporter 4; IR-Dependent IRS-1/PI3K/Akt pathway; L6 myotubes; FPP; farnesyl pyrophosphate; FTI; farnesyltransferase inhibitor; GGPP; geranylgeranyl pyrophosphate; GGTI; geranylgeranyltransferase 1 inhibitor; GLUT4;
Cloning, expression and functional characterization of two sesquiterpene synthase genes from moso bamboo (Phyllostachys edulis)
Keywords: (E, E)-farnesol; Heterologous expression; Moso bamboo; (E)-nerolidol; Pichia pastoris; Sesquiterpene; FPP; farnesyl pyrophosphate; YPD; yeast extract-peptone-dextrose; BMGY; buffered glycerol-complex medium; BMMY; buffered methanol-complex medium; MM;
Efficient phototrophic production of a high-value sesquiterpenoid from the eukaryotic microalga Chlamydomonas reinhardtii
Keywords: PcPs; Pogostemon cablin Benth patchoulol synthase; TAP; Tris Acetate Phosphate medium; T2P; TAP medium without acetate and 2X phosphate content; FPP; farnesyl diphosphate; GPP; geranyl diphosphate; GGPP; geranylgeranyl diphosphate; CDW; Cell dry weight; Y
Simvastatin enhances NMDA receptor GluN2B expression and phosphorylation of GluN2B and GluN2A through increased histone acetylation and Src signaling in hippocampal CA1 neurons
Keywords: Simvastatin; Hippocampus; NMDA receptors; Farnesyl-pyrophosphate (FPP); Histone acetylation of GluN2B; Src; α7nAChR; α7 nicotinic acetylcholine receptor; AD; Alzheimer's disease; Aβ; β-amyloid peptides; ACSF; artificial cerebral spinal fluid; AHP; aft
De novo characterization of the Lycium chinense Mill. leaf transcriptome and analysis of candidate genes involved in carotenoid biosynthesis
Keywords: CHYB; β-carotene hydroxylase; COG; Cluster of Orthologous Group; CRTISO; carotene isomerase; DMAPP; dimethylallyl pyrophosphate; Gbp; gigabase pairs; GGPP; geranylgeranyl pyrophosphate; GGPS; geranylgeranyl diphosphate synthase; GO; Gene Ontology; IPP; i
GGPPS deficiency aggravates CCl4-induced liver injury by inducing hepatocyte apoptosis
Keywords: GGPPS; geranylgeranyl diphosphate synthase; GGPP; geranylgeranyl pyrophosphate; HMG-CoA; 3-hydroxy-3-methylglutarylcoenzyme A; CCl4; carbon tetrachloride; ECM; extracellular matrix; COL1A1; type I collagen; HCV; hepatitis C virus; NASH; non-alcoholic stea
Inhibition of the mevalonate pathway ameliorates anoxia-induced down-regulation of FKBP12.6 and intracellular calcium handling dysfunction in H9c2 cells
Keywords: DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethylsulfoxide; FKBP; FK506-binding protein; FPP; farnesyl pyrophosphate; GAPDH; glyceraldehyde phosphate dehydrogenase; GGPP; geranylgeranyl pyrophosphate; HMG-CoA; 3-hydroxy-3-methylglutaryl-coenzyme A;
Enhanced accumulation of carotenoids in sweetpotato plants overexpressing IbOr-Ins gene in purple-fleshed sweetpotato cultivar
Keywords: Sweetpotato; Orange gene; Carotenoid; Anthocyanin; Zeaxanthin; ABA; abscisic acid; ANS; anthocyanidin synthase; AsA; ascorbic acid; CaMV; cauliflower mosaic virus; CCDs; carotenoid cleavage dioxygenases; CHY-β; β-carotene hydroxylase; CRTI; carotenoid d
Production of dammarane-type sapogenins in rice by expressing the dammarenediol-II synthase gene from Panax ginseng C.A. Mey
Keywords: DS; Dammarenediol-II synthase; T-DNA; Transfer-DNA; HPLC; High performance liquid chromatography; PPD; 20 (S)-Protopanaxadiol; PPT; 20 (S)-Protopanaxatriol; DAD; Dammarenediol-II; ESI; Electrospray ionization; EIC; Extracted ion chromatogram; PSY; Phyto
Efficient diterpene production in yeast by engineering Erg20p into a geranylgeranyl diphosphate synthase
Keywords: geranyl diphosphate; GPP; dimethylallyl diphosphate; DMAPP; isopentenyl diphosphate; IPP; farnesyl diphosphate; FPP; geranylgeranyl diphosphate; GGPP; nerolidol; NOH; farnesol; FOH; geraniol; GOH; linalool; LOH; geranylgeraniol; GGOH; geranyllinalool; GLO
In vitro studies in a myelogenous leukemia cell line suggest an organized binding of geranylgeranyl diphosphate synthase inhibitors
Keywords: DGBP; digeranyl bisphosphonate; FDPS; farnesyl diphosphate synthase; FOH; farnesol; FPP; farnesyl diphosphate; GGDPS; geranylgeranyl diphosphate synthase; GGOH; geraniol; GGPP; geranylgeranyl diphosphate; GGPTase; geranylgeranyl protein transferase; HMG-C
Identification of laticifer-specific genes and their promoter regions from a natural rubber producing plant Hevea brasiliensis
Keywords: ABA; abscisic acid; cPT; cis-prenyltransferase; EST; expressed sequence tag; FPP; E,E-farnesyl diphosphate; GGPP; E,E,E-geranylgeranyl diphosphate; GO; gene ontology; PI; protease inhibitor-like protein; REF; Rubber Elongation Factor; RP; rubber particle;
Substrate specificity of undecaprenyl diphosphate synthase from the hyperthermophilic archaeon Aeropyrum pernix
Keywords: DMAPP; dimethylallyl diphosphate; FPP; farnesyl diphosphate; GGPP; geranylgeranyl diphosphate; GFPP; geranylfarnesyl diphosphate; GPP; geranyl diphosphate; HexPP; hexaprenyl diphosphate; IPP; isopentenyl diphosphate; UPP; undecaprenyl diphosphate; Isopren