دانلود مقالات ISI درباره Pdk-1 + ترجمه فارسی

اهداف مولکولی اثر واربورگ و سیتوکین های التهابی در پاتوژنز پرفشاری خون عروق ریوی

Molecular targets of the Warburg effect and inflammatory cytokines in the pathogenesis of pulmonary artery hypertension

Keywords: DCA; dichloroacetate; FAO; fatty acid oxidation; GO; glucose oxidation; HIF-1; hypoxia-inducible factor 1; CaL channels; L-type calcium channels; NFATs; nuclear factor of activated T cells; NO; nitric oxide; MCT-PAH; monocrotaline-induced PAH; PAH; pulmon

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

ترکیب ترکیبی دارو: ترکیبی از اسید فروولیک و متفورمین به عنوان درمان ضد دیابتی

Hybrid drug combination: Combination of ferulic acid and metformin as anti-diabetic therapy

Keywords: Synergy; Ferulic acid; Metformin; Anti-diabetic agents; AMPK, PI-3K; Akt; protein kinase B; AMPK; AMP-activated protein kinase; DM; Diabetes mellitus; G6Pase; glucose-6-phosphatase; IRS; Insulin receptor substrate; LD50; lethal dose 50%; PDK-1; 3-phosphoi

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2017 سفارش ترجمه

یک رژیم غذایی با چربی بالا باعث ایجاد تفاوت های جنسیتی در متابولیسم لیپیدی های کبدی و نیتریت / نیترات در موش صحرایی می شود

A high fat diet induces sex-specific differences in hepatic lipid metabolism and nitrite/nitrate in rats

Keywords: High fat diet; Sex differences; Insulin resistance; Liver metabolism; Nitrite/nitrate; Akt; protein kinase B; FAT/CD36; fatty acid translocase/cluster of differentiation 36; FFA; free fatty acids; Glut-2; glucose transporter 2; HF; high fat; HOMA; homeost

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

نقش مس در رگرسیون هیپرتروفی قلبی

Role of copper in regression of cardiac hypertrophy

Keywords: Copper; Cardiac hypertrophy; CCO; Angiogenesis; VEGFRs; HIF-1; ANG-1; angiopoietin-1; ANG-2; angiopoietin-2; ANP; atrial natriuretic peptide; ATOX1; antioxidant 1; ATP; adenosine triphosphate; BNP; B-type natriuretic peptide; BNIP3; BCL2/adenovirus E1B 19

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2015 سفارش ترجمه

بررسی وابستگی متیلاتی بیان ژن آلفا فاکتور 1 القاء شده با هیپوکسی با عامل فاکتور کایسو

Methylation-dependent regulation of hypoxia inducible factor-1 alpha gene expression by the transcription factor Kaiso

Keywords: HIF1/HIF-1; hypoxia inducible factor-1; VHL; von Hippel-Lindau; HRE; hypoxia response element; CBP; CREB binding protein; MBD; methyl-CpG binding domain; SRA; SET and RING finger-associated; KBS; Kaiso binding site; ANOVA; analysis of variance; FDR; fal

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2015 سفارش ترجمه

Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver

Keywords: AFL; alcoholic fatty liver; ALD; alcoholic liver disease; ALT; alanine transaminase; AMPK; AMP-activated protein kinase; AST; aspartate transaminase; CMZ; chlormethiazole; CYP2E1; cytochrome P4502E1; 4-HNE; 4-hydroxynonenal; IGF-1; insulin-like growth fac

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Novel nuclear translocation of inositol polyphosphate 4-phosphatase is associated with cell cycle, proliferation and survival

Keywords: INPP4A; inositol polyphosphate 4 phosphatase type I enzyme; LMB; leptomycin B; PtdIns(P); phosphatidyl inositol phosphate; Ins(1,4,5)P3; Inositol 1,4,5 tris-phosphate; PDK-1; phosphoinositide-dependent kinase-1; mTORC2; mammalian target of rapamycin compl

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Agmatine potentiates neuroprotective effects of subthreshold concentrations of ketamine via mTOR/S6 kinase signaling pathway

Keywords: Agmatine; Akt; HT22; Ketamine; Neuroprotection; p70S6 kinase; PSD95; 4E-BPs; 4E binding proteins; ANOVA; analysis of variance; DMEM; Dulbecco's Modified Eagle Medium; ECT; electroconvulsive therapy; CUS; chronic unpredictable stress; FST; forced swim test

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Regulation of protein kinase C-related kinase (PRK) signalling by the TPα and TPβ isoforms of the human thromboxane A2 receptor: Implications for thromboxane- and androgen- dependent neoplastic and epigenetic responses in prostate cancer

Keywords: ADT; androgen deprivation therapy; AR; androgen receptor; ARE; androgen response element; AA; arachidonic acid; BCR; biochemical recurrence; ChIP; chromatin immunoprecipitation; COX; cyclooxygenase/prostaglandin G2/H2 synathase; CRPC; castrate resistant p

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

MiR-1271 upregulated by saturated fatty acid palmitate provokes impaired insulin signaling by repressing INSR and IRS-1 expression in HepG2 cells

Keywords: microRNA; miR-1271; Saturated fatty acid; Palmitate; Insulin resistance; INSR; IRS-1; Akt2; v-akt murine thymoma viral oncogene homolog 2; C/EBPα; CCAAT/enhancer binding protein alpha; ER; endoplasmic reticulum; FOXQ1; forkhead box Q1; GPC3; glypican 3;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Time-dependent PPARγ Modulation of HIF-1α Signaling in Hypoxic Pulmonary Artery Smooth Muscle Cells

Keywords: PPARγ; HIF-1α; PDK-1; Vascular smooth muscle cell; Pulmonary hypertension

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

The lncRNA MALAT1, acting through HIF-1α stabilization, enhances arsenite-induced glycolysis in human hepatic L-02 cells

Keywords: lncRNAs; long non-coding RNAs; MALAT1; metastasis-associated lung adenocarcinoma transcript 1; HIFs; hypoxia inducible factors; VHL; Von Hippel-Lindau; Glut-4; glucose transporter type 4; Eno-1; enolase-1; HK-2; hexokinase-2; PDK-1; pyruvate dehydrogena

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Condensed catechins and their potential health-benefits

Keywords: ACE; angiotensin I-converting enzyme; AMPK; AMP-activated protein kinase; AUC; area under the curve; BGL; blood glucose level; CaMKK; Ca2+/camodulin-dependent protein kinase kinase; COX; cyclooxygenases; EC; (−)-epicatechin; EDRF; endothelium derived-re

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

PIM kinase (and Akt) biology and signaling in tumors

Keywords: PIM kinases; Akt; Oncogenes; Cancer; Therapeutic resistance; AML; acute myeloid leukemia; AMPK; AMP activated protein kinase; CXCR-4; C-X-C chemokine receptor type 4; EGFR; epidermal growth factor receptor; EBV; Epstein-Barr virus; FLT3; FMS-like ty

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2015 سفارش ترجمه

PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease

Keywords: AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid precursor protein; 4EBP1; eukaryotic translation initiation factor 4E (eIF-4E)-binding protein-1; FOXO; Forkhead box-O class transcription factors; FMRP; Fragile-X mental retardation protein; GSK3β;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Akt signaling and freezing survival in the wood frog, Rana sylvatica

Keywords: Freeze tolerance; miRNA; FOXO1; PDK-1; PTEN; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Nox4 and diabetic nephropathy: With a friend like this, who needs enemies?

Keywords: 20-HETE; 20-hydroxyeicosatetraenoic acid; AA; arachidonic acid; AGE; advanced glycation end-product; Akt/PKB; Akt/protein kinase B; AMPK; AMP-activated protein kinase; Ang II; angiotensin II; AOPP; advanced oxidation protein product; AT1; angiotensin II t

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

SBF-1, a synthetic steroidal glycoside, inhibits melanoma growth and metastasis through blocking interaction between PDK1 and AKT3

Keywords: SBF-1; Melanoma; PDK-1; AKT3; Metastasis

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Is targeting eNOS a key mechanistic insight of cardiovascular defensive potentials of statins?

Keywords: AFCAPS/TexCAPS; Air Force/Texas Coronary Atherosclerosis Prevention Study; ARMYDA; Atorvastatin for Reduction of MYocardial Damage during Angioplasty; ASCOT-LLA; The Anglo-Scandinavian Cardiac Outcomes Trial- Lipid-Lowering Arm; AURORA; A Study to Evaluat

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

CKD712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, inhibits the lipopolysaccharide-stimulated secretion of HMGB1 by inhibiting PI3K and classical protein kinase C

Keywords: CLP; cecum and ligation puncture; HMGB1; high mobility group box 1 protein; iNOS; inducible nitric oxide synthase; PBMo; peripheral blood monocytes; PDK-1; phosphoinositide-dependent kinase 1; PKC; protein kinase C; cPKC; classical PKC; Sepsis; Inflammati

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Oxidative stress, insulin signaling, and diabetes

Keywords: AGE; advanced glycated end product; CAP; c-Cbl-associated protein; DAG; diacylglycerol; eNOS; endothelial nitric oxide synthase; ERK; extracellular signal-regulated kinase; ETC; electron transport chain; GH; growth hormone; GLUT4; glucose transporter type

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

The lipid-modulating effects of a CD4-specific recombinant antibody correlate with ZAP-70 segregation outside membrane rafts

Keywords: ADAP; adhesion- and degranulation-promoting adapter protein; Carma1; caspase-recruitment domain [CARD]-membrane-associated guanylate kinase [MAGUK] protein 1; CDR3; complementary determining region 3; GM1; ganglioside M1; GC; gas chromatography; HER2; hum

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

c-Cbl acts as a mediator of Src-induced activation of the PI3K-Akt signal transduction pathway during TRAIL treatment

Keywords: c-Cbl; Casitas B-lineage lymphoma; DD; death domain; DISC; death-inducing signaling complex; DMEM; Dulbecco's modified Eagle's medium; DR4; TRAIL-R1; DR5; TRAIL-R2; DTT; dithiothreitol; EGF; epidermal growth factor; EGFR; EGF receptor; EGTA; ethylene glyc

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Benzo[c][2,7]naphthyridines as inhibitors of PDK-1

Keywords: PDK-1; PDK-1 inhibitor; Benzo[c][2,7]naphthyridines

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

TIS21/BTG2/PC3 and cyclin D1 are key determinants of nuclear diacylglycerol kinase-ζ-dependent cell cycle arrest

Keywords: cdk; cyclin dependent kinase; DG; diacylglycerol; DGK; diacylglycerol kinase; ECL; enhanced chemiluminescence; GSK; glycogen synthase kinase; mTOR; mammalian Target Of Rapamycin; NLS; nuclear localization signal; p70S6K; p70S6 kinase; PA; phosphatidic aci

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

The C-terminus of PRK2/PKNγ is required for optimal activation by RhoA in a GTP-dependent manner

Keywords: PRK2; PKC; Rho; PDK-1; Signal transduction

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: Optimization of BX-517

Keywords: Kinases; PDK-1; AKT; PI 3-kinase; Cancer; Antitumor agent

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKCα

Keywords: PI 3-kinase; phosphoinositide 3-kinase; PKB; protein kinase B; PDK-1; phosphoinositide-dependent kinase-1; PKC; protein kinase C; mTOR; mammalian target of rapamycin; c48/80; compound 48/80; BAPTA; bis-(o-aminophemoxy)-ethane-N,N,N′,N′-tetraacetic aci

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

The SARS-Coronavirus Membrane protein induces apoptosis through modulating the Akt survival pathway

Keywords: Cytochrome c; Drosophila; HEK293T; PDK-1; Severe Acute Respiratory Syndrome

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Atypical protein kinase C in glucose metabolism

Keywords: PKC; protein kinase C; aPKC; atypical isoforms of PKC; Par6; partitioning-defective protein 6; Par3; partitioning-defective protein 3; PDK-1; 3-phosphoinositide-dependent protein kinase 1; PI3K; phosphatidylinositol 3-kinase; EGFP; enhanced greenfluoresce

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Phosphorylation at the hydrophobic site of protein kinase C Apl II is increased during intermediate term facilitation

Keywords: Aplysia; learning and memory; phosphoinositide dependent kinase I; persistent protein kinase; rapamycin; autophosphorylation; PDBu; phorbol dibutyrate; PDK-1; phosphoinositide-dependent kinase I; PI-3 kinase; phosphoinositide-3 kinase; PKC; protein kinase

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

The very C-terminus of protein kinase Cɛ is critical for the full catalytic competence but its hydrophobic motif is dispensable for the interaction with 3-phosphoinositide-dependent kinase-1

Keywords: aPKC; atypical PKC; cPKC; classic PKC; MD; molecular dynamics; nPKC; novel PKC; PAGE; polyacrylamide gel electrophoresis; PDK-1; 3-phosphoinositide-dependent kinase-1; PKA; cAMP-dependent protein kinase; PKB; protein kinase B; PKC; protein kinase C; RMSD;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

The last five amino acid residues at the C-terminus of PRK1/PKN is essential for full lipid responsiveness

Keywords: aPKC; atypical PKC; cPKC; classic PKC, MD molecular dynamics; nPKC; novel PKC; PAGE; polyacrylamide gel electrophoresis; PRK1; protein kinase C-related kinase 1; PKC; protein kinase C; PKA; cAMP-dependent protein kinase; PKB; protein kinase B; PDK-1; 3-ph

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2005 سفارش ترجمه

The Role of Protein Kinase C in Gastrointestinal Function and Disease

Keywords: PDK-1; phosphoinositide-dependent kinase-1; PK; protein kinase;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2005 سفارش ترجمه