The lncRNA MALAT1, acting through HIF-1α stabilization, enhances arsenite-induced glycolysis in human hepatic L-02 cells

Based on our data, we propose a model depicting a role of MALAT1 in the regulation of arsenite-enhanced glycolysis. In L-02 cells, MALAT1 is induced by arsenite. With arsenite exposure, MALAT1 blocks HIF-1α hydroxylation and then disrupts the HIF-1α-VHL interaction, stabilizes HIF-1α and increases expression of glycolytic enzymes, such as HK-2, Eno-1, and Glut-4 thereby promoting glycolysis; HIF-1α enhances arsenite-induced glycolysis may through p53 and NF-κB. In summary, in L-02 cells exposed to arsenite, MALAT1 is involved in the Warburg effect.79