A high fat diet induces sex-specific differences in hepatic lipid metabolism and nitrite/nitrate in rats

The proposed mechanism by which a HF diet induces altered hepatic lipid metabolism and affects regulation of hepatic iNOS expression and nitrite/nitrate production in a sex-specific manner in rats. Altered hepatic lipid metabolism caused by a HF diet influences the iNOS/NO pathway and thus promotes IR by attenuating insulin action. Among other mechanisms, large amounts of nitrite/nitrate produced in other tissues may easily enter the liver and inhibit iNOS protein expression, but also disturb insulin action.