Keywords: وابسته به فسفوینوزیته kinase-1; High fat diet; Sex differences; Insulin resistance; Liver metabolism; Nitrite/nitrate; Akt; protein kinase B; FAT/CD36; fatty acid translocase/cluster of differentiation 36; FFA; free fatty acids; Glut-2; glucose transporter 2; HF; high fat; HOMA; homeost
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Keywords: وابسته به فسفوینوزیته kinase-1; Copper; Cardiac hypertrophy; CCO; Angiogenesis; VEGFRs; HIF-1; ANG-1; angiopoietin-1; ANG-2; angiopoietin-2; ANP; atrial natriuretic peptide; ATOX1; antioxidant 1; ATP; adenosine triphosphate; BNP; B-type natriuretic peptide; BNIP3; BCL2/adenovirus E1B 19
Keywords: وابسته به فسفوینوزیته kinase-1; Akt; protein kinase B; DHA; docosahexaenoic acid; ERK; extracellular signal-regulated protein kinase; NAPE; N-acylphosphatidylethanolamine; PC; phosphatidylcholine; PDK1; phosphoinositide-dependent kinase-1; PE; phosphatidylethanolamine; PEMT; phosphatidy
Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention
Keywords: وابسته به فسفوینوزیته kinase-1; ER; estrogen receptor; mTORC2; mammalian target of rapamycin complex 2; PDK1; phosphoinositide-dependent kinase-1; PH; pleckstrin homology; PI3K; phosphatidylinositol 3-kinase; PX; Phox; SGK; serum and glucocorticoid inducible protein kinase; SGK; AKT; PI
MiR-183 promotes preadipocyte differentiation by suppressing Smad4 in goats
Keywords: وابسته به فسفوینوزیته kinase-1; PPARγ; peroxisome proliferator-activated receptor γ; C/EBPα; CCAAT/enhancer binding protein α; FAS; fatty acid synthase; TGFβ; transforming growth factor β; LRP6; low density lipoprotein receptor related protein 6; SREBP-1c; sterol regulatory elemen
Re-evaluating the role of FOXOs in cancer
Keywords: وابسته به فسفوینوزیته kinase-1; RTK; receptor tyrosine kinase; GF; growth factor; PI3K; Phosphatidylinositol-4,5-bisphosphate 3-kinase; PKB; protein kinase B; AKT; RAC-alpha serine/threonine-protein kinase; FOXO; forkhead box O; GFR; growth factor receptor; PDPK1; Phosphoinositide-depen
Influence of silibinin and β-β-dimethylacrylshikonin on chordoma cells
Keywords: وابسته به فسفوینوزیته kinase-1; Chordoma; β-β-dimethylacrylshikonin; Silibinin; Apoptosis; ACTB; actin beta; AKT; AKT serine/threonine kinase; BAD; BCL2 associated agonist of cell death; BAK; BCL2 antagonist/killer; BAX; BCL2 associated X protein; BCL-2; B cell leukemia/lymphoma 2; BH
Novel nuclear translocation of inositol polyphosphate 4-phosphatase is associated with cell cycle, proliferation and survival
Keywords: وابسته به فسفوینوزیته kinase-1; INPP4A; inositol polyphosphate 4 phosphatase type I enzyme; LMB; leptomycin B; PtdIns(P); phosphatidyl inositol phosphate; Ins(1,4,5)P3; Inositol 1,4,5 tris-phosphate; PDK-1; phosphoinositide-dependent kinase-1; mTORC2; mammalian target of rapamycin compl
Agmatine potentiates neuroprotective effects of subthreshold concentrations of ketamine via mTOR/S6 kinase signaling pathway
Keywords: وابسته به فسفوینوزیته kinase-1; Agmatine; Akt; HT22; Ketamine; Neuroprotection; p70S6 kinase; PSD95; 4E-BPs; 4E binding proteins; ANOVA; analysis of variance; DMEM; Dulbecco's Modified Eagle Medium; ECT; electroconvulsive therapy; CUS; chronic unpredictable stress; FST; forced swim test
Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity
Keywords: وابسته به فسفوینوزیته kinase-1; Vascular smooth muscle; Vasoproliferative disease; Vascular smooth muscle cell; Phenotype switching; Signalling pathways; AJ; adherens junction; ApoE; apolipoprotein E; BMP; bone morphogenetic protein; CAD; coronary artery diseases; CADASIL; cerebral auto
MiR-1271 upregulated by saturated fatty acid palmitate provokes impaired insulin signaling by repressing INSR and IRS-1 expression in HepG2 cells
Keywords: وابسته به فسفوینوزیته kinase-1; microRNA; miR-1271; Saturated fatty acid; Palmitate; Insulin resistance; INSR; IRS-1; Akt2; v-akt murine thymoma viral oncogene homolog 2; C/EBPα; CCAAT/enhancer binding protein alpha; ER; endoplasmic reticulum; FOXQ1; forkhead box Q1; GPC3; glypican 3;
Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme
Keywords: وابسته به فسفوینوزیته kinase-1; PDK1 inhibitors; Kinase inhibitors; Oxindole derivatives; Glioblastoma; GBM stem cells; Multi-target therapy; PI3K; phosphatidylinositol-3-kinase; PDK1; phosphoinositide-dependent kinase-1; GSK3; Glycogen synthase kinase 3; CHK1; Checkpoint kinase-1; Akt;
The structural basis of action of vanadyl (VO2+) chelates in cells
Keywords: وابسته به فسفوینوزیته kinase-1; acac; acetylacetonate, as in bis(acetylacetonato)oxidovanadium(IV) or VO(acac)2; alx; allixin; ASP; acylation-stimulating protein; CHO; Chinese hamster ovary; ENDOR; electron nuclear double resonance; EGFR; epidermal growth factor receptor; EPR; electron
PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease
Keywords: وابسته به فسفوینوزیته kinase-1; AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid precursor protein; 4EBP1; eukaryotic translation initiation factor 4E (eIF-4E)-binding protein-1; FOXO; Forkhead box-O class transcription factors; FMRP; Fragile-X mental retardation protein; GSK3β;
β-Arrestin signal complex plays a critical role in adipose differentiation
Keywords: وابسته به فسفوینوزیته kinase-1; GHSR1a; growth hormone secretagogue receptor type 1a; PPARγ; peroxisome proliferator-activated receptor; C/EBPα; CCAAT/enhancer-binding protein α; C/EBPβ; CCAAT/enhancer-binding protein β; C/EBPδ; CCAAT/enhancer-binding protein δ; PI3K; phosphatidy
c-Jun N-terminal kinase controls a negative loop in the regulation of glial fibrillary acidic protein expression by retinoic acid
Keywords: وابسته به فسفوینوزیته kinase-1; GFAP; c-Jun N-terminal kinase; retinoic acid; neural precursor cells; BMP-2; bone morphogenetic protein-2; DNA-PKcs; DNA-protein kinase catalytic subunit; ERK; extracelular-regulated kinase; GFAP; glial fibrillary acidic protein; GSK-β; glycogen synthase
Destabilization of PDK1 by Hsp90 inactivation suppresses hepatitis C virus replication through inhibition of PRK2-mediated viral RNA polymerase phosphorylation
Keywords: وابسته به فسفوینوزیته kinase-1; Hsp90; heat shock protein 90; HCV; hepatitis C virus; RdRp; RNA-dependent RNA polymerase; 17-DMAG; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin; PDK1; phosphoinositide-dependent kinase-1; PRK2; protein kinase C-related kinase 2; Hsp90 inhibitor;
Methanol extract of Osbeckia stellata suppresses lipopolysaccharide- and HCl/ethanol-induced inflammatory responses by inhibiting Src/Syk and IRAK1
Keywords: وابسته به فسفوینوزیته kinase-1; Os-ME; methanol extract of Osbeckia stellata; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; TNF-α; tumor necrosis factor-alpha; ERK; extracellular signal-related kinase; TLR; toll-like receptor; MAPK; mitogen
Redox-regulating role of insulin: The essence of insulin effect
Keywords: وابسته به فسفوینوزیته kinase-1; 4-HNE; 4-hydroxynonenal; 8-OHdG; 8-hydroxydeoxyguanosine; 8-OHG; 8-hydroxyguanine; 8-iso-PGF2α; 8-iso-prostaglandin F2α; AD; Alzheimer's disease; AIDS; acquired immunodeficiency syndrome; Akt; protein kinase B; AMI; acute myocardial infarction; APS; a
c-Cbl acts as a mediator of Src-induced activation of the PI3K-Akt signal transduction pathway during TRAIL treatment
Keywords: وابسته به فسفوینوزیته kinase-1; c-Cbl; Casitas B-lineage lymphoma; DD; death domain; DISC; death-inducing signaling complex; DMEM; Dulbecco's modified Eagle's medium; DR4; TRAIL-R1; DR5; TRAIL-R2; DTT; dithiothreitol; EGF; epidermal growth factor; EGFR; EGF receptor; EGTA; ethylene glyc
Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells
Keywords: وابسته به فسفوینوزیته kinase-1; Vestibular schwannoma; Malignant schwannoma HMS-97; Neurofibromatosis type 2; The Neurofibromatosis 2 (NF2) gene; Merlin; PI3K/AKT pathway; OSU-03012; Cyclooxygenase-2 inhibitor; Phosphoinositide-dependent kinase-1; Xenograft
Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKCα
Keywords: وابسته به فسفوینوزیته kinase-1; PI 3-kinase; phosphoinositide 3-kinase; PKB; protein kinase B; PDK-1; phosphoinositide-dependent kinase-1; PKC; protein kinase C; mTOR; mammalian target of rapamycin; c48/80; compound 48/80; BAPTA; bis-(o-aminophemoxy)-ethane-N,N,Nâ²,Nâ²-tetraacetic aci
Dynamics of signaling by PKA
Keywords: وابسته به فسفوینوزیته kinase-1; cAMP; cyclic-3â², 5â²-adenosine monophosphate; PKA; cAMP-dependent protein kinase; PKI; heat stable protein kinase A inhibitor; PDK1; phosphoinositide-dependent kinase-1; ATP; adenosine triphosphate; ADP; adenosine diphosphate; D/D domain; dimerization/
The Role of Protein Kinase C in Gastrointestinal Function and Disease
Keywords: وابسته به فسفوینوزیته kinase-1; PDK-1; phosphoinositide-dependent kinase-1; PK; protein kinase;
Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease
Keywords: وابسته به فسفوینوزیته kinase-1; Aβ; β-amyloid; AD; Alzheimer's disease; AIF; apoptosis-inducing factor; ALS; amyotrophic lateral sclerosis; Apaf-1; apoptotic protease-activating factor; APC; adenomatous polyposis coli; APP; amyloid precursor protein; BrdU; bromodeoxyuridine; CARD; cas