کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8289457 | 1536308 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides
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کلمات کلیدی
LPSKeapnuclear factor-erythroid-2-related factor 28-Nitro-cGMP15d-PGJ2HNECBSiNOSERKPTMGSHCSEGSTNrf215-deoxy-Δ12,14-Prostaglandin J2 - 15-deoxy-Δ12،14-پروستاگلاندین J24-hydroxy-2-nonenal - 4-هیدروکسی-2 غیرنالcystathionine γ-lyase - cystationine γ-lyaseLC-MS/MS - LC-MS / MSNOx - NOXMyocardial infarction - آنفارکتوس میوکاردposttranslational modification - اصلاح posttranslationalNADPH oxidase - اکسیداز NADPH cystathionine β-synthase - سیستاتیونین β-سنتازRedox signaling - سیگنالینگ Redoxlipopolysaccharide - لیپوپلی ساکاریدretinoblastoma gene product - محصول ژن رتینوبلاستوماKelch-like ECH-associated protein 1 - پروتئین مرتبط با ECH کلچ 1liquid chromatography tandem mass spectrometry - کروماتوگرافی مایع اسپکترومتری دو طرفهextracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولیGlutathione - گلوتاتیونglutathione S-transferase - گلوتاتیون S-ترانسفراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Reactive oxygen (oxidant) and free radical species are known to cause nonspecific damage of various biological molecules. The oxidant toxicology is developing an emerging concept of the physiological functions of reactive oxygen species in cell signaling regulation. Redox signaling is precisely modulated by endogenous electrophilic substances that are generated from reactive oxygen species during cellular oxidative stress responses. Among diverse electrophilic molecular species that are endogenously generated, 8-nitroguanosine 3â²,5â²-cyclic monophosphate (8-nitro-cGMP) is a unique second messenger whose formation, signaling, and metabolism in cells was recently clarified. Most important, our current studies revealed that reactive cysteine persulfides that are formed abundantly in cells are critically involved in the metabolism of 8-nitro-cGMP. Modern redox biology involves frontiers of cell research and stem cell research; medical and clinical investigations of infections, cancer, metabolic syndrome, aging, and neurodegenerative diseases; and other fields. 8-Nitro-cGMP-mediated signaling and metabolism in cells may therefore be potential targets for drug development, which may lead to discovery of new therapeutic agents for many diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Biochemistry and Biophysics - Volume 595, 1 April 2016, Pages 140-146
Journal: Archives of Biochemistry and Biophysics - Volume 595, 1 April 2016, Pages 140-146
نویسندگان
Shigemoto Fujii, Tomohiro Sawa, Motohiro Nishida, Hideshi Ihara, Tomoaki Ida, Hozumi Motohashi, Takaaki Akaike,