15-Deoxy-Δ12,14-prostaglandin J2 inhibits IL-13 production in T cells via an NF-κB-dependent mechanism

► 15d-PGJ2 decreased IL-13 mRNA transcription and secretion in activated T cells. ► IL-13 inhibition by 15d-PGJ2 is independent of PPAR-γ. ► The nuclear factor-κB mediates the 15d-PGJ2-dependent down regulation of IL-13.