Inhibition of interferon-γ-induced nitric oxide production by 10-hydroxy-trans-2-decenoic acid through inhibition of interferon regulatory factor-8 induction

► 10H2DA is a major lipid component of royal jelly. ► 10H2DA inhibited IFN-γ-induced NO production. ► IFN-γ-induced NF-κB, but not STAT1, activation was inhibited by 10H2DA. ► 10H2DA inhibited NF-κB activation via inhibition of IRF-8 and TNF-α induction. ► 10H2DA is a unique modulator of IFN-γ-mediated cellular responses.