کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10930131 1093415 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
BMP antagonists: Their roles in development and involvement in pathophysiology
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
BMP antagonists: Their roles in development and involvement in pathophysiology
چکیده انگلیسی
Bone morphogenetic proteins (BMPs) are phylogenetically conserved signaling molecules that belong to the transforming growth factor (TGF)-β superfamily, and are involved in the cascades of body patterning and morphogenesis. The activities of BMPs are precisely regulated by certain classes of molecules that are recently recognized as BMP antagonists. BMP antagonists function through direct association with BMPs, thus prohibiting BMPs from binding their cognate receptors. In this review, the classification and functions of BMP antagonists will be discussed, especially focusing on the new family of tissue-specific BMP antagonists composed of uterine sensitization-associated gene 1 (USAG-1) and sclerostin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine & Growth Factor Reviews - Volume 16, Issue 3, June 2005, Pages 309-317
نویسندگان
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