کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10931184 | 1093620 | 2016 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Borderless regulates glial extension and axon ensheathment
ترجمه فارسی عنوان
بی حد و مرز، گسترش زگیل و تنظیم اکسون را تنظیم می کند
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
چکیده انگلیسی
Ensheathment of axons by glial processes is essential for normal brain function. While considerable progress has been made to define molecular and cellular mechanisms underlying the maintenance of axon ensheathment, less is known about molecular details of early events for the wrapping of axons by glial processes in the developing nervous system. In this study, we investigate the role of the transmembrane protein Borderless (Bdl) in the developing Drosophila visual system. Bdl belongs to the immunoglobulin (Ig) superfamily, and its in vivo function is unknown. We show that Bdl is expressed in wrapping glia (WG) in the developing eye disc. Cell-type-specific transgene rescue and knockdown indicate that Bdl is specifically required in WG for the extension of glial processes along photoreceptor axons in the optic lobe, and axon ensheathment. Our results identify Bdl as a novel glia-specific cell-surface recognition molecule in regulating glial extension and axon ensheathment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 414, Issue 2, 15 June 2016, Pages 170-180
Journal: Developmental Biology - Volume 414, Issue 2, 15 June 2016, Pages 170-180
نویسندگان
Scott Cameron, Yixu Chen, Yong Rao,