کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10931218 | 1093622 | 2016 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Contribution of hedgehog signaling to the establishment of left-right asymmetry in the sea urchin
ترجمه فارسی عنوان
مشارکت سیگنال جگری برای ایجاد عدم تقارن چپ و راست در دریاچه یخ زده
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کلمات کلیدی
سمت چپ نامتقارن چپ، جوجه تیغی، طبیعی، سیلیا، جوجه تیغی دریایی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
چکیده انگلیسی
Most bilaterians exhibit a left-right asymmetric distribution of their internal organs. The sea urchin larva is notable in this regard since most adult structures are generated from left sided embryonic structures. The gene regulatory network governing this larval asymmetry is still a work in progress but involves several conserved signaling pathways including Nodal, and BMP. Here we provide a comprehensive analysis of Hedgehog signaling and it's contribution to left-right asymmetry. We report that Hh signaling plays a conserved role to regulate late asymmetric expression of Nodal and that this regulation occurs after Nodal breaks left-right symmetry in the mesoderm. Thus, while Hh functions to maintain late Nodal expression, the molecular asymmetry of the future coelomic pouches is locked in. Furthermore we report that cilia play a role only insofar as to transduce Hh signaling and do not have an independent effect on the asymmetry of the mesoderm. From this, we are able to construct a more complete regulatory network governing the establishment of left-right asymmetry in the sea urchin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 411, Issue 2, 15 March 2016, Pages 314-324
Journal: Developmental Biology - Volume 411, Issue 2, 15 March 2016, Pages 314-324
نویسندگان
Jacob F. Warner, Esther L. Miranda, David R. McClay,