Balancing on the crest - Evidence for disruption of the enteric ganglia via inappropriate lineage segregation and consequences for gastrointestinal function

► Neurons and glia of the enteric nervous system derive from neural crest. ► Mouse models that alter enteric ganglia are reviewed. ► Ganglia architecture and composition require normal neural crest differentiation. ► Deficits in enteric ganglia are related to clinical gastrointestinal disorders.