Nemo regulates cell dynamics and represses the expression of miple, a midkine/pleiotrophin cytokine, during ommatidial rotation

► The ommatidial rotation process has been characterized in vivo. ► nmo is required in cone cells for correct ommatidial rotation. ► nmo regulates the expression of genes encoding adhesion and signaling molecules. ► Transcriptional repression of miple by Nmo is required during ommatidial rotation. ► miple interacts with ptp99A and the E-cadherin-β-catenin complex.