The nucleolar protein Viriato/Nol12 is required for the growth and differentiation progression activities of the Dpp pathway during Drosophila eye development

► We performed an eye-targeted double-RNAi screen for Vito interactors. ► vito interacts genetically with members of the Dpp signaling pathway. ► Dpp-dependent eye disc growth and differentiation is modulated by Vito. ► Nucleolar Vito is required for correct Dpp signaling in eye primordium.