Integrin signaling is required for maintenance and proliferation of intestinal stem cells in Drosophila

► The function of Integrin signaling in fly intestinal stem cells was investigated. ► αPS1 (mew),αPS3(scb) and βPS (mys) are expressed in ISCs for maintenance. ► Integrin signaling is required for ISC proliferation but not survival. ► Disruption of integrin triggers cell cycle arrest and prevents tumorigenesis.