The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway regulates developmental cerebral-vascular stability via prenylation-dependent signalling pathway

► Loss of HMGCR function disrupts vascular stability in developing zebrafish. ► Vascular defects are reversed with mevalonate or geranylgeranyl pyrophosphate. ► Loss of GGTase-I function phenocopies loss of HMGCR. ► The HMGCR pathway affects vascular stability via prenylation-dependent signalling.