Thyroid hormone and retinoic acid interact to regulate zebrafish craniofacial neural crest development

► Craniofacial and ocular development requires thyroid hormone. ► Thyroid hormone regulates neural crest migration, survival and proliferation. ► Thyroid hormone regulates genes (pitx2, twist1) linked with craniofacial defects. ► Dynamic changes in thyroid hormone and retinoic acid pattern cranial neural crest.