Keywords: AFib; atrial fibrillation; TSG; tumor suppressor gene; CM; cardiomyocytes; GWAS; genome-wide association studies; SR; sinus rhythm; SNP; small nucleotide polymorphism; ECRG4; esophageal cancer related gene-4; ZFHX3; zinc finger homeobox protein-3; Cx; con
مقالات ISI (ترجمه نشده)
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Keywords: Teeth; Teleost; pitx2; shh; bmp4; Modularity; ARS;
Keywords: 5-HT; serotonin (5-hydroxytryptamine); A83-01; TGF-β kinase/activin receptor-like kinase inhibitor; ACTB; actin beta/beta-actin; ASCL1; achaete-scute homolog 1 (MASH1); ASOs; anti-sense oligonucleotides; Bcl-xL; b-cell lymphoma-extra large; BDNF; brain d
Keywords: action potentials; antagomirs; gene therapy; genetic loci; genetic predisposition to disease; microRNAs; AF; atrial fibrillation; APD; action potential duration; CHF; congestive heart failure; DNA; deoxyribonucleic acid; GWAS; genome-wide association stud
Keywords: Predictive biomarkers; Pathology response; Esophageal cancer; Chemo(radio)therapy; Meta-analysis; ESCC; Esophageal squamous cell carcinoma; AC; Adenocarcinoma; TS; Thymidylate synthase; Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma 2; CYFRA21-1;
Keywords: Craniofacial; Thyroid hormone; Neural crest; Migration; Pitx2; Twist1; Retinoic acid; Retinoid X receptor; Pharyngeal arch; Eye development;
Bovine pituitary homeobox 2 (PITX2): mRNA expression profiles of different alternatively spliced variants and association analyses with growth traits
Keywords: SNP; single nucleotide polymorphism; CNV; copy number variation; PITX2; pituitary homeobox 2; PITX; paired-like homeodomain transcription factor; PITX2-V1; PITX2-variant 1; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; NCBI; National Center of Biotechn
Transcriptome profiling reveals candidate cleft palate-related genes in cultured Chinese sturgeons (Acipenser sinensis)
Keywords: CL; craniofacial defect affecting the lip only; CLP; craniofacial defect affecting the lip and palate; CP; craniofacial defect affecting the palate only; IRF6; Interferon regulatory factor 6; MAFB; MAF bZIP transcription factor B; ARHGAP29; Rho GTPase act
Significance of PITX2 Promoter Methylation in Colorectal Carcinoma Prognosis
Keywords: Biomarker; Colorectal cancer; Epigenetic; Methylation; PITX2;
The left-right asymmetry of liver lobation is generated by Pitx2c-mediated asymmetries in the hepatic diverticulum
Keywords: Xenopus; Liver; Left-right asymmetry; Endoderm; Morphogenesis; Pitx2;
4q25 microdeletion encompassing PITX2: A patient presenting with tetralogy of Fallot and dental anomalies without ocular features
Keywords: PITX2; 4q25; Tetralogy of fallot; Axenfeld-rieger syndrome; Haploinsufficiency;
Atrial fibrillation is associated with hypermethylation in human left atrium, and treatment with decitabine reduces atrial tachyarrhythmias in spontaneously hypertensive rats
Keywords: AF; atrial fibrillation; AT; atrial tachyarrhythmia; BMI; body mass index; Cu, Zn-SOD; copper, zinc superoxide dismutase; GEO; Gene Expression Omnibus; GO; Gene Ontology; Hprt; hypoxanthine-guanine phosphoribosyltransferase; LA; left atrium; MnSOD; mangan
Exploration of dairy goat PITX2 alternative splice events and differential isoform expression
Keywords: PITX2; paired-liked homodomain transcription factor 2; PITX2-V1; Paired-liked homodomain transcription factor 2-V1; PITX2-V2; paired-liked homodomain transcription factor 2-V2; PCR; polymerase chain Reaction; RT-PCR; reverse transcript - polymerase chain
Gene signatures of postoperative atrial fibrillation in atrial tissue after coronary artery bypass grafting surgery in patients receiving β-blockers
Keywords: AF; atrial fibrillation; BB; β-blocker; CABG; coronary artery bypass grafting; CPB; cardiopulmonary bypass; EGFR; epidermal growth factor receptor; eQTL; expression quantitative trait loci; ES; enrichment score; FAM126B; family with sequence similarity 1
PITX2 loss-of-function mutation contributes to tetralogy of Fallot
Keywords: CHD; congenital heart disease; TOF; tetralogy of Fallot; ASD; atrial septal defect; NCBI; National Center for Biotechnical Information; PCR; polymerase chain reaction; EVS; Exome Variant Server; SNP; single nucleotide polymorphism; ANF-luc; atrial natriur
Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature
Keywords: ASD; atrial septal defects; AP; action potential; AVN; atrioventricular node; ChIP-Seq; chromatin immunoprecipitation-sequencing; Cx; Connexin; DAPI; 4,6-diamidino-2-phenylindol; E; embryonic day; FC; fold change; Gapdh; glyceraldehyde-3-phosphate dehydro
Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs
Keywords: Pitx2; Axenfeld-Rieger syndrome; Left-right asymmetry; Elovl6; Genome editing; Zebrafish;
PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers
Keywords: antiarrhythmic drugs; atrial fibrillation; drug targets; electrophysiology; personalized medicine; rhythm control; AAD; antiarrhythmic drug; APD; action potential duration; ERP; effective refractory period; HEK; human embryonic kidney; LA; left atrium; LA
Suppressing Pitx2 inhibits proliferation and promotes differentiation of iHepSCs
Keywords: Pitx2; paired like homeodomain transcription factor 2; iHepSCs; induced hepatic stem cells; shRNA; small hairpin RNA; Alb; albumin; DAPI; 4â²6-diamidino-2-phenylindole; DiI-ac-LDL; DiI-labelled acetylated low-density lipoprotein; Aat; α-anti-trypsin; Tt
Expression of the transcription factor PITX2 in ameloblastic carcinoma
Keywords: Ameloblastic carcinoma; Ameloblastoma; WNT cell signalling pathway; Odontogenesis; Transcription factor; PITX2;
Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members
Keywords: 5-HT; 5-hydroxytryptamine, serotonin; A549; non-small cell lung cancer cell line; AD; Alzheimer's disease; ADPKD; autosomal dominant polycystic kidney disease; Aire; autoimmune regulator; AP-1; activator protein 1; APP; amyloid precursor protein; AREB6; Z
Identification of the GTPase-activating protein DEP domain containing 1B (DEPDC1B) as a transcriptional target of Pitx2
Keywords: GTPase signaling; Transcriptional regulation; Pitx2; DEPDC1B;
PITX2 associates with PTIP-containing histone H3 lysine 4 methyltransferase complex
Keywords: PITX2; MLL4/KMT2D; PTIP; Histone H3 lysine 4 (H3K4); Histone lysine methyltransferase (HKMT);
Genetic analysis of the TBX1 gene promoter in indirect inguinal hernia
Keywords: DSVs; DNA sequence variants; FGF8; fibroblast growth factor 8; FGF10; fibroblast growth factor 10; FoxA2; forkhead box factor A2; IIH; indirect inguinal hernia; Pitx2; paired-like homeodomain factor 2; SNPs; single nucleotide polymorphisms; TBX1; T-box tr
Signals from the lens and Foxc1 regulate the expression of key genes during the onset of corneal endothelial development
Keywords: Peri-ocular mesenchyme; Corneal endothelial development; Lens; Foxc1; Pitx2;
Utility and limits of Hprt-Cre technology in generating mutant mouse embryos
Keywords: Hprt-Cre; Homozygous null mutants; Mouse; Efficiency; Cyp26b1; Shh; Pitx2; Raldh2; Fgfr2IIIb; Compound mutants
Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development
Keywords: Wls; Ventral body wall; Pitx2; Abdominal musculature; Ectoderm;
A truncating SCN5A mutation combined with genetic variability causes sick sinus syndrome and early atrial fibrillation
Keywords: AF; atrial fibrillation; AP; action potential; BrS; Brugada syndrome; GFP; green fluorescent protein; HEK293; human embryonic kidney 293; HP; holding potential; INa; inward sodium current; LQTS; long QT syndrome; SNP; single nucleotide polymorphism; SSS;
A potential molecular pathogenesis of cardiac/laterality defects in Oculo-Facio-Cardio-Dental syndrome
Keywords: Notch signaling; Pitx2; Left-right patterning; Xenopus; OFCD syndrome;
Methylmercury-induced changes in gene transcription associated with neuroendocrine disruption in largemouth bass (Micropterus salmoides)
Keywords: 11-KT; 11-ketotestosterone; ABCB7; ATP-binding cassette sub-family B (MDR/TAP), member 7; AMACR; alpha-methylacyl-CoA racemase; AR; androgen receptor; BEST; Biomonitoring of Environmental Status and Trends; BRD4; bromodomain containing 4; CASP3; caspase 3
Self-regulated left-right asymmetric expression of Pitx2c in the developing mouse limb
Keywords: Left-right asymmetry; Limb; Pitx2;
FGF9-Pitx2-FGF10 signaling controls cecal formation in mice
Keywords: Pitx2; Fgf9; Fgf10; Cecum; Agenesis; Development;
Pitx2 is a Critical Early Regulatory Gene in Normal Cecal Development
Keywords: Pitx2; cecum; development; agenesis
Isolation, sequence characterization, expression pattern analysis of porcine Pitx2c gene
Keywords: Pig; Pitx2; Expression; Meat quality;
Pitx2 is an upstream activator of extraocular myogenesis and survival
Keywords: Extraocular muscles; Myogenesis; Pitx2; Eye development; Inducible knockout;
Pitx2c modulates Pax3+/Pax7+ cell populations and regulates Pax3 expression by repressing miR27 expression during myogenesis
Keywords: Pitx2; Myogenesis; Pax3; Pax7;
Retinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2
Keywords: Retinoic acid; Wnt signaling; Perioptic mesenchyme; Cornea; Eyelid; Raldh1; Raldh3; Pitx2; Dkk2; Axin2; Wnt5a;
Prediction of regulatory networks in mouse abdominal wall
Keywords: GO; gene ontology; SSTF; sequence specific transcription factor; CRM; cis-regulatory module; RMA; robust multichip average; WT; wild type; HET; heterozygote; MUT; mutant; MGI; mouse genome informatics; Pitx2; Homeobox; Development; Gene expression analysi
At least two expressed genes for transcription factors Pitx2 and Rpx are present in common carp and are upregulated during winter acclimatization
Keywords: Pitx2; Rpx; Gene expression; Carp fish; Seasonal control; Acclimatization
Wnt/Lef1 signaling acts via Pitx2 to regulate somite myogenesis
Keywords: Chicken embryo; Wnt signaling; Myogenesis; Lef1; Pitx2; Proliferation;
β-Catenin Regulates Mesenchymal Progenitor Cell Differentiation During Hepatogenesis
Keywords: hepatogenesis; Wnt; β-Catenin; stellate cell; Pitx2; Dermo1
Tbx1 regulates progenitor cell proliferation in the dental epithelium by modulating Pitx2 activation of p21
Keywords: Tbx1; PITX2; p21; DiGeorge syndrome; Tooth development
Many roads lead to primary autosomal recessive microcephaly
Keywords: 53BP1; tumor-suppressor protein p53 binding protein 1; APC; anaphase-promoting complex; ASPM; abnormal spindle-like, microcephaly associated protein; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and RAD3-related protein; BACH1; BRCA1-ass
Pitx2, a β-catenin-regulated transcription factor, regulates the differentiation of outer root sheath cells cultured in vitro
Keywords: β-Catenin; Follicular differentiation; Outer root sheath cells; Pitx2
Expression patterns of Shh, Ptc2, Raldh3, Pitx2, Isl1, Lim3 and Pax6 in the developing chick hypophyseal placode and Rathke’s pouch
Keywords: Hedgehog; Patched; Raldh3; Pitx2; Lim3; Isl1; Pax6; Hypophyseal placode; Rathke’s pouch; Pituitary; Chick
Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells
Keywords: HSC; Ki-67; Lef1; Pitx2; Tcf1; TWS119; Wnt
Iris development in vertebrates; genetic and molecular considerations
Keywords: Iris; Pax6; Pitx2; FoxC1; Aniridia; Axenfeld-Rieger syndrome; Iris transdifferentiation;
Mechanisms underlying pituitary hypoplasia and failed cell specification in Lhx3-deficient mice
Keywords: Isl1; Sf1; NR5A1; Notch2; Tpit; Neurod1; Tle3; Pitx1; Pitx2; LIM3; P-LIM
Expression pattern of the homeodomain transcription factor Pitx2 during muscle development
Keywords: Homeobox; Transcription factors; Pitx2; Lbx1; Pax3; MyoD; Myosin heavy chain; Muscle development; Somites; Branchial arches; Somatopleure; Skeletal muscles; Craniofacial muscles; Abdominal muscles
Roles of the Foxj1 and Inv genes in the left–right determination of internal organs in mice
Keywords: Left–right axis; Foxj1; Inv; Aortic arch; Right pulmonary isomerism; Mutant mice; Pitx2