A network of PUF proteins and Ras signaling promote mRNA repression and oogenesis in C. elegans

► Two PUF RNA-binding protein groups control different processes in oogenesis. ► PUF-3/11 and PUF-5/6/7 repress translation of distinct and common mRNAs. ► Ras-MapKinase pathway promotes translational repression by PUF-5/6/7. ► Ras-MapKinase regulates PUF-5 protein. ► Ras-MapKinase and PUF-5/6/7 cooperate to control oocyte organization.