Regulation of locomotion and motoneuron trajectory selection and targeting by the Drosophila homolog of Olig family transcription factors

► Drosophila Oli is expressed in embryonic ventral motoneuron subtypes. ► oli controls axonal trajectory selection and muscle targeting during embryogenesis. ► Oli acts as part of a conserved transcription factor ensemble that includes Hb9. ► Oli is expressed in postembryonic leg-innervating motoneuron lineages. ► Oli is required in glutamatergic neurons for adult locomotion.