Concomitant lack of MMP9 and uPA disturbs physiological tissue remodeling

► Combined lack of MMP9 and uPA activity is critical for tissue remodeling. ► MMP9 and uPA are important for gestation and tissue repair. ► Tissue- and event-specific functional redundancy between MMP9 and uPA. ► Compensatory upregulation of uPA during wound healing in the absence of MMP9.