EBF proteins participate in transcriptional regulation of Xenopus muscle development

▶ Ebf genes are expressed in developing Xenopus muscle tissues. ▶ EBF protein activity is required for normal Xenopus skeletal muscle development. ▶ Microarray screen identified muscle related targets of EBF transcriptional activity. ▶ EBF is sufficient and required for expression of some muscle related genes in vivo. ▶ The EBF target MyoD upregulates expression of ebf genes suggesting a feedback loop.