Differential requirements for Myocyte Enhancer Factor-2 during adult myogenesis in Drosophila

► Drosophila adults lacking MEF2 during muscle development were generated. ► MEF2 is required for myoblast fusion in adult myogenesis. ► MEF2 is dispensable for actin gene expression during adult myogenesis. ► MEF2 shows a partial, but not complete, requirement for adult muscle differentiation following myoblast fusion.