Xenopus Zic3 controls notochord and organizer development through suppression of the Wnt/β-catenin signaling pathway

► Zic3 has a role in organizer and notochord development. ► Zic3 attenuates Wnt/β-catenin signaling. ► Zic3 reduces β-catenin nuclear accumulation and promotes the degradation of β-catenin. ► Zic3 physically interacts with Tcf1 and XIC which can both influence β-catenin function. ► Zic3 may fine-tune Wnt/β-catenin signaling activity in vertebrate development.