Proliferating cells in suborbital tissue drive eye migration in flatfish

►We found that eye migration in flatfish is caused by cell proliferation in the suborbital tissue of blind side. ►We corrected the misunderstanding that eye migration is driven by the cranial asymmetry. ►We found that cranial asymmetry depends on the eye migration. ►Eye-symmetric flatfish with a bottom-dwelling lifestyle were first time produced artificially.