A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway

►A mutagenesis screen identifies 24 genes involved in gonad formation. ►These genes preferentially affect the behavior of the somatic gonad rather than the germ cells. ►Gonad formation is regulated by both DE-cadherin-dependent and independent pathways. ►The slit/robo pathway is essential for organogenesis of the gonad.