کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10932668 | 1093744 | 2011 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation](/preview/png/10932668.png)
چکیده انگلیسی
⺠LrrB null (lrrB-) slugs are highly defective in phototaxis and thermotaxis, perhaps because the anterior, pstO prestalk sub-region of the slug is aberrant. ⺠There are many changes in gene expression in the null mutant, especially in prestalk-specific transcripts. ⺠The posterior, pstB sub-population of the slug is absent in the lrrB- mutant and the derivative structures are aberrant or missing. ⺠The lrrB- mutant is highly defective in ecmB induction by the polyketide DIF-1 but only marginally defective in ecmA induction, so the mutation partially uncouples these two inductive events. ⺠SH2 domain signaling in Dictyostelium mirrors that of animal cells in utilizing single adaptor proteins in multiple signaling pathways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 353, Issue 2, 15 May 2011, Pages 290-301
Journal: Developmental Biology - Volume 353, Issue 2, 15 May 2011, Pages 290-301
نویسندگان
Christopher Sugden, Susan Ross, Sarah J. Annesley, Christian Cole, Gareth Bloomfield, Alasdair Ivens, Jason Skelton, Paul R. Fisher, Geoffrey Barton, Jeffrey G. Williams,