Ectodermal WNT/β-catenin signaling shapes the mouse face

► Stabilization of β-catenin in ectoderm alters facial morphology. ► Loss of β-catenin in facial ectoderm causes hypoplasia of maxilla and mandible. ► Stabilization of β-catenin in facial ectoderm activates Fgf4 and Fgf8.