کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10932765 | 1093748 | 2011 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modulation of N-cadherin junctions and their role as epicenters of differentiation-specific actin regulation in the developing lens
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
âºIn this manuscript we present novel findings that link cadherin junctions to tissue morphogenesis, in vivo, through their regulation of actin filament assembly. These studies were performed in the embryonic lens, a tissue ideally suited to questions regarding the mechanisms of morphogenesis. Acquisition of the lens cell differentiated phenotype requires lens epithelial cells to undergo a rapid and coordinated elongation. Here, we show that α-catenin is involved in differentiation-state specific maturation of N-cadherin junctions which are sites of recruitment of the actin regulators cortactin and Arp3 in vivo. We show that these N-cadherin junctions are responsible for organization of a cortical actin cytoskeleton and for the elongation of differentiating lens fiber cells, a process that is central to the morphogenesis of the lens. We believe our findings provide valuable information relevant to understanding the formation and function of many differentiated tissues.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 349, Issue 2, 15 January 2011, Pages 363-377
Journal: Developmental Biology - Volume 349, Issue 2, 15 January 2011, Pages 363-377
نویسندگان
Michelle Leonard, Liping Zhang, Ni Zhai, Ahmad Cader, Yim Chan, Roberta B. Nowak, Velia M. Fowler, A. Sue Menko,