Wnt/β-catenin dependent cell proliferation underlies segmented lateral line morphogenesis

►A signaling feedback circuit involving the Wnt/β-catenin and Fgf signaling pathways regulates multiple aspects of lateral line morphogenesis by coordinating proliferation, migration and epithelial maturation. ►Segmentation of the lateral line is driven by a novel mechanism that relies on dynamic cell behaviors such as cell migration and cell proliferation. ►Periodicity of lateral line segmentation is determined by the rate of cell proliferation.