کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10933197 1093775 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mast cells contribute to the stromal microenvironment in mammary gland branching morphogenesis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Mast cells contribute to the stromal microenvironment in mammary gland branching morphogenesis
چکیده انگلیسی
The stromal microenvironment regulates mammary gland branching morphogenesis. We have observed that mast cells are present in the mammary gland throughout its postnatal development and, in particular, are found around the terminal end buds and ductal epithelium of the pubertal gland. Mast cells contribute to allergy, inflammatory diseases, and cancer development but have not been implicated in normal development. Genetic and pharmacological disruption of mast cell function in the mammary gland revealed that mast cells are involved in rapid proliferation and normal duct branching during puberty, and this effect is independent of macrophage recruitment, which also regulates mammary gland development. For mast cells to exert their effects on normal morphogenesis required activation of their serine proteases and degranulation. Our observations reveal a novel role for mast cells during normal pubertal development in the mammary gland.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 337, Issue 1, 1 January 2010, Pages 124-133
نویسندگان
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