کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10933294 1093788 2009 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interfering with Wnt signalling alters the periodicity of the segmentation clock
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Interfering with Wnt signalling alters the periodicity of the segmentation clock
چکیده انگلیسی
Somites are embryonic precursors of the ribs, vertebrae and certain dermis tissue. Somite formation is a periodic process regulated by a molecular clock which drives cyclic expression of a number of clock genes in the presomitic mesoderm. To date the mechanism regulating the period of clock gene oscillations is unknown. Here we show that chick homologues of the Wnt pathway genes that oscillate in mouse do not cycle across the chick presomitic mesoderm. Strikingly we find that modifying Wnt signalling changes the period of Notch driven oscillations in both mouse and chick but these oscillations continue. We propose that the Wnt pathway is a conserved mechanism that is involved in regulating the period of cyclic gene oscillations in the presomitic mesoderm.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 330, Issue 1, 1 June 2009, Pages 21-31
نویسندگان
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