کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10933295 1093788 2009 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Estrogen receptor subtype β2 is involved in neuromast development in zebrafish (Danio rerio) larvae
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Estrogen receptor subtype β2 is involved in neuromast development in zebrafish (Danio rerio) larvae
چکیده انگلیسی
Estrogens are known to play a role in both reproductive and non-reproductive functions in mammals. Estrogens and their receptors are involved in the development of the central nervous system (brain development, neuronal survival and differentiation) as well as in the development of the peripheral nervous system (sensory-motor behaviors). In order to decipher possible functions of estrogens in early development of the zebrafish sensory system, we investigated the role of estrogen receptor β2 (ERβ2) by using a morpholino (MO) approach blocking erβ2 RNA translation. We further investigated the development of lateral line organs by cell-specific labeling, which revealed a disrupted development of neuromasts in morphants. The supporting cells developed and migrated normally. Sensory hair cells, however, were absent in morphants' neuromasts. Microarray analysis and subsequent in situ hybridizations indicated an aberrant activation of the Notch signaling pathway in ERβ2 morphants. We conclude that signaling via ERβ2 is essential for hair cell development and may involve an interaction with the Notch signaling pathway during cell fate decision in the neuromast maturation process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 330, Issue 1, 1 June 2009, Pages 32-43
نویسندگان
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